Kelland LR - Search Results

1

Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.

Farrell N, Kelland LR, Roberts JD, Van Beusichem M. Farrell N, et al. Among authors: kelland lr. Cancer Res. 1992 Sep 15;52(18):5065-72. Cancer Res. 1992. PMID: 1516063

2

BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin.

Manzotti C, Pratesi G, Menta E, Di Domenico R, Cavalletti E, Fiebig HH, Kelland LR, Farrell N, Polizzi D, Supino R, Pezzoni G, Zunino F. Manzotti C, et al. Among authors: kelland lr. Clin Cancer Res. 2000 Jul;6(7):2626-34. Clin Cancer Res. 2000. PMID: 10914703

3

Synthesis, characterization, and cytotoxicity of trifunctional dinuclear platinum complexes: comparison of effects of geometry and polyfunctionality on biological activity.

Qu Y, Rauter H, Soares Fontes AP, Bandarage R, Kelland LR, Farrell N. Qu Y, et al. Among authors: kelland lr. J Med Chem. 2000 Aug 10;43(16):3189-92. doi: 10.1021/jm990536z. J Med Chem. 2000. PMID: 10956227

4

Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.

Hegmans A, Qu Y, Kelland LR, Roberts JD, Farrell N. Hegmans A, et al. Among authors: kelland lr. Inorg Chem. 2001 Nov 19;40(24):6108-14. doi: 10.1021/ic010509a. Inorg Chem. 2001. PMID: 11703107

5

Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile.

Ma ES, Bates WD, Edmunds A, Kelland LR, Fojo T, Farrell N. Ma ES, et al. Among authors: kelland lr. J Med Chem. 2005 Sep 8;48(18):5651-4. doi: 10.1021/jm050539d. J Med Chem. 2005. PMID: 16134932

6

Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.

Harris AL, Yang X, Hegmans A, Povirk L, Ryan JJ, Kelland L, Farrell NP. Harris AL, et al. Inorg Chem. 2005 Dec 26;44(26):9598-600. doi: 10.1021/ic051390z. Inorg Chem. 2005. PMID: 16363817

7

Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.

Hegmans A, Kasparkova J, Vrana O, Kelland LR, Brabec V, Farrell NP. Hegmans A, et al. Among authors: kelland lr. J Med Chem. 2008 Apr 10;51(7):2254-60. doi: 10.1021/jm070813z. Epub 2008 Mar 14. J Med Chem. 2008. PMID: 18338842 Free PMC article.

8

A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity.

Kelland LR, Barnard CF, Mellish KJ, Jones M, Goddard PM, Valenti M, Bryant A, Murrer BA, Harrap KR. Kelland LR, et al. Cancer Res. 1994 Nov 1;54(21):5618-22. Cancer Res. 1994. PMID: 7923207

9

Comparison of cellular accumulation and cytotoxicity of cisplatin with that of tetraplatin and amminedibutyratodichloro(cyclohexylamine)platinum(IV) (JM221) in human ovarian carcinoma cell lines.

Mistry P, Kelland LR, Loh SY, Abel G, Murrer BA, Harrap KR. Mistry P, et al. Among authors: kelland lr. Cancer Res. 1992 Nov 15;52(22):6188-93. Cancer Res. 1992. PMID: 1423261

10

Kelland LR, Mistry P, Abel G, Loh SY, O'Neill CF, Murrer BA, Harrap KR. Kelland LR, et al. Cancer Res. 1992 Jul 15;52(14):3857-64. Cancer Res. 1992. PMID: 1617660

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