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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L. Picard F, et al. Among authors: guarente l. Nature. 2004 Jun 17;429(6993):771-6. doi: 10.1038/nature02583. Epub 2004 Jun 2. Nature. 2004. PMID: 15175761 Free PMC article.
Calorie restriction--the SIR2 connection.
Guarente L, Picard F. Guarente L, et al. Cell. 2005 Feb 25;120(4):473-82. doi: 10.1016/j.cell.2005.01.029. Cell. 2005. PMID: 15734680 Free article. Review.
Mammalian SIRT1 represses forkhead transcription factors.
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Motta MC, et al. Among authors: guarente l. Cell. 2004 Feb 20;116(4):551-63. doi: 10.1016/s0092-8674(04)00126-6. Cell. 2004. PMID: 14980222 Free article.
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Bordone L, et al. Among authors: guarente l. PLoS Biol. 2006 Feb;4(2):e31. doi: 10.1371/journal.pbio.0040031. Epub 2005 Dec 27. PLoS Biol. 2006. PMID: 16366736 Free PMC article.
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.
Liszt G, Ford E, Kurtev M, Guarente L. Liszt G, et al. Among authors: guarente l. J Biol Chem. 2005 Jun 3;280(22):21313-20. doi: 10.1074/jbc.M413296200. Epub 2005 Mar 28. J Biol Chem. 2005. PMID: 15795229 Free article.
Molecular links between aging and adipose tissue.
Picard F, Guarente L. Picard F, et al. Among authors: guarente l. Int J Obes (Lond). 2005 Mar;29 Suppl 1:S36-9. doi: 10.1038/sj.ijo.0802912. Int J Obes (Lond). 2005. PMID: 15711582
305 results