Fujii N - Search Results

1

Two orthogonal approaches to overcome multi-drug resistant HIV-1s: development of protease inhibitors and entry inhibitors based on CXCR4 antagonists.

Tamamura H, Fujii N. Tamamura H, et al. Among authors: fujii n. Curr Drug Targets Infect Disord. 2004 Jun;4(2):103-10. doi: 10.2174/1568005043340957. Curr Drug Targets Infect Disord. 2004. PMID: 15180458 Review.

2

Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.

Tamamura H, Omagari A, Hiramatsu K, Oishi S, Habashita H, Kanamoto T, Gotoh K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Bioorg Med Chem. 2002 May;10(5):1417-26. doi: 10.1016/s0968-0896(01)00419-9. Bioorg Med Chem. 2002. PMID: 11886804

3

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.

Tamamura H, Hiramatsu K, Miyamoto K, Omagari A, Oishi S, Nakashima H, Yamamoto N, Kuroda Y, Nakagawa T, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Bioorg Med Chem Lett. 2002 Mar 25;12(6):923-8. doi: 10.1016/s0960-894x(02)00041-0. Bioorg Med Chem Lett. 2002. PMID: 11958995

4

The therapeutic potential of CXCR4 antagonists in the treatment of HIV.

Fujii N, Nakashima H, Tamamura H. Fujii N, et al. Expert Opin Investig Drugs. 2003 Feb;12(2):185-95. doi: 10.1517/13543784.12.2.185. Expert Opin Investig Drugs. 2003. PMID: 12556213 Review.

5

Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N. Tamamura H, et al. Among authors: fujii n. J Med Chem. 2003 Apr 24;46(9):1764-8. doi: 10.1021/jm020537i. J Med Chem. 2003. PMID: 12699395

6

T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer.

Tamamura H, Hori A, Kanzaki N, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. FEBS Lett. 2003 Aug 28;550(1-3):79-83. doi: 10.1016/s0014-5793(03)00824-x. FEBS Lett. 2003. PMID: 12935890 Free article.

7

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.

Tamamura H, Hiramatsu K, Kusano aS, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Org Biomol Chem. 2003 Nov 7;1(21):3656-62. doi: 10.1039/b306473p. Org Biomol Chem. 2003. PMID: 14649896

8

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.

Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. Org Biomol Chem. 2003 Nov 7;1(21):3663-9. doi: 10.1039/b306613b. Org Biomol Chem. 2003. PMID: 14649897

9

Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.

Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. FEBS Lett. 2004 Jul 2;569(1-3):99-104. doi: 10.1016/j.febslet.2004.05.056. FEBS Lett. 2004. PMID: 15225616 Free article.

10

Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.

Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N. Tamamura H, et al. Among authors: fujii n. J Med Chem. 2005 Jan 27;48(2):380-91. doi: 10.1021/jm049429h. J Med Chem. 2005. PMID: 15658852

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