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3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
J Med Chem. 2004 Jun 17;47(13):3367-80. doi: 10.1021/jm031145u.
J Med Chem. 2004.
PMID: 15189033
A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1,3-thiazoles as potential CDK5 inhibitors.
Larsen SD, Stachew CF, Clare PM, Cubbage JW, Leach KL.
Larsen SD, et al. Among authors: clare pm.
Bioorg Med Chem Lett. 2003 Oct 20;13(20):3491-5. doi: 10.1016/s0960-894x(03)00726-1.
Bioorg Med Chem Lett. 2003.
PMID: 14505655
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The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism.
Clare PM, Poorman RA, Kelley LC, Watenpaugh KD, Bannow CA, Leach KL.
Clare PM, et al.
J Biol Chem. 2001 Dec 21;276(51):48292-9. doi: 10.1074/jbc.M102034200. Epub 2001 Oct 16.
J Biol Chem. 2001.
PMID: 11604388
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