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Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors--reducing the lipophilicity of the arachidonyl chain isostere.
Walters I, Bennion C, Connolly S, Croshaw PJ, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Stein L, Wells E, John Withnall W. Walters I, et al. Among authors: murray d. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3645-9. doi: 10.1016/j.bmcl.2004.05.024. Bioorg Med Chem Lett. 2004. PMID: 15203135
Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.
Connolly S, Bennion C, Botterell S, Croshaw PJ, Hallam C, Hardy K, Hartopp P, Jackson CG, King SJ, Lawrence L, Mete A, Murray D, Robinson DH, Smith GM, Stein L, Walters I, Wells E, Withnall WJ. Connolly S, et al. Among authors: murray d. J Med Chem. 2002 Mar 14;45(6):1348-62. doi: 10.1021/jm011050x. J Med Chem. 2002. PMID: 11882004
Tyrosine kinase inhibitors. 13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Thompson AM, Murray DK, Elliott WL, Fry DW, Nelson JA, Showalter HD, Roberts BJ, Vincent PW, Denny WA. Thompson AM, et al. Among authors: murray dk. J Med Chem. 1997 Nov 21;40(24):3915-25. doi: 10.1021/jm970366v. J Med Chem. 1997. PMID: 9397172
Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors.
Rewcastle GW, Murray DK, Elliott WL, Fry DW, Howard CT, Nelson JM, Roberts BJ, Vincent PW, Showalter HD, Winters RT, Denny WA. Rewcastle GW, et al. Among authors: murray dk. J Med Chem. 1998 Feb 26;41(5):742-51. doi: 10.1021/jm970641d. J Med Chem. 1998. PMID: 9513602
Early life microbial succession in the gut follows common patterns in humans across the globe.
Fahur Bottino G, Bonham KS, Patel F, McCann S, Zieff M, Naspolini N, Ho D, Portlock T, Joos R, Midani FS, Schüroff P, Das A, Shennon I, Wilson BC, O'Sullivan JM, Britton RA, Murray DM, Kiely ME, Taddei CR, Beltrão-Braga PCB, Campos AC, Polanczyk GV, Huttenhower C, Donald KA, Klepac-Ceraj V. Fahur Bottino G, et al. Among authors: murray dm. Nat Commun. 2025 Jan 14;16(1):660. doi: 10.1038/s41467-025-56072-w. Nat Commun. 2025. PMID: 39809768 Free PMC article.
3,464 results