Zimhony O - Search Results

1

Characterization of Mycobacterium smegmatis expressing the Mycobacterium tuberculosis fatty acid synthase I (fas1) gene.

Zimhony O, Vilchèze C, Jacobs WR Jr. Zimhony O, et al. J Bacteriol. 2004 Jul;186(13):4051-5. doi: 10.1128/JB.186.13.4051-4055.2004. J Bacteriol. 2004. PMID: 15205406 Free PMC article.

2

Conditionally replicating luciferase reporter phages: improved sensitivity for rapid detection and assessment of drug susceptibility of Mycobacterium tuberculosis.

Carrière C, Riska PF, Zimhony O, Kriakov J, Bardarov S, Burns J, Chan J, Jacobs WR Jr. Carrière C, et al. Among authors: zimhony o. J Clin Microbiol. 1997 Dec;35(12):3232-9. doi: 10.1128/jcm.35.12.3232-3239.1997. J Clin Microbiol. 1997. PMID: 9399525 Free PMC article.

3

Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis.

Zimhony O, Cox JS, Welch JT, Vilchèze C, Jacobs WR Jr. Zimhony O, et al. Nat Med. 2000 Sep;6(9):1043-7. doi: 10.1038/79558. Nat Med. 2000. PMID: 10973326

4

Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli.

Zimhony O, Vilchèze C, Arai M, Welch JT, Jacobs WR Jr. Zimhony O, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):752-4. doi: 10.1128/AAC.01369-06. Epub 2006 Nov 13. Antimicrob Agents Chemother. 2007. PMID: 17101678 Free PMC article.

5

Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.

Ngo SC, Zimhony O, Chung WJ, Sayahi H, Jacobs WR Jr, Welch JT. Ngo SC, et al. Among authors: zimhony o. Antimicrob Agents Chemother. 2007 Jul;51(7):2430-5. doi: 10.1128/AAC.01458-06. Epub 2007 May 7. Antimicrob Agents Chemother. 2007. PMID: 17485499 Free PMC article.

6

Mutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.

Baughn AD, Deng J, Vilchèze C, Riestra A, Welch JT, Jacobs WR Jr, Zimhony O. Baughn AD, et al. Among authors: zimhony o. Antimicrob Agents Chemother. 2010 Dec;54(12):5323-8. doi: 10.1128/AAC.00529-10. Epub 2010 Sep 27. Antimicrob Agents Chemother. 2010. PMID: 20876380 Free PMC article.

7

Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase I.

Sayahi H, Zimhony O, Jacobs WR Jr, Shekhtman A, Welch JT. Sayahi H, et al. Among authors: zimhony o. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4804-7. doi: 10.1016/j.bmcl.2011.06.055. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21775138 Free PMC article.

8

Analogs of the antituberculous agent pyrazinamide are competitive inhibitors of NADPH binding to M. tuberculosis fatty acid synthase I.

Sayahi H, Pugliese KM, Zimhony O, Jacobs WR Jr, Shekhtman A, Welch JT. Sayahi H, et al. Among authors: zimhony o. Chem Biodivers. 2012 Nov;9(11):2582-96. doi: 10.1002/cbdv.201200291. Chem Biodivers. 2012. PMID: 23161636

9

AcpM, the meromycolate extension acyl carrier protein of Mycobacterium tuberculosis, is activated by the 4'-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis.

Zimhony O, Schwarz A, Raitses-Gurevich M, Peleg Y, Dym O, Albeck S, Burstein Y, Shakked Z. Zimhony O, et al. Biochemistry. 2015 Apr 14;54(14):2360-71. doi: 10.1021/bi501444e. Epub 2015 Apr 1. Biochemistry. 2015. PMID: 25785780

10

Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli.

Baron S, Peleg Y, Grunwald J, Morgenstern D, Elad N, Peretz M, Albeck S, Levin Y, Welch JT, DeWeerd KA, Schwarz A, Burstein Y, Diskin R, Shakked Z, Zimhony O. Baron S, et al. Among authors: zimhony o. PLoS One. 2018 Sep 24;13(9):e0204457. doi: 10.1371/journal.pone.0204457. eCollection 2018. PLoS One. 2018. PMID: 30248156 Free PMC article.

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