Kayed R - Search Results

1

Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.

Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Sanbe A, et al. Among authors: kayed r. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10132-6. doi: 10.1073/pnas.0401900101. Epub 2004 Jun 25. Proc Natl Acad Sci U S A. 2004. PMID: 15220483 Free PMC article.

2

The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties.

Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. Soreghan B, et al. Among authors: kayed r. Neuromolecular Med. 2002;1(1):81-94. doi: 10.1385/NMM:1:1:81. Neuromolecular Med. 2002. PMID: 12025818

3

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe CG, Langen R. Török M, et al. Among authors: kayed r. J Biol Chem. 2002 Oct 25;277(43):40810-5. doi: 10.1074/jbc.M205659200. Epub 2002 Aug 13. J Biol Chem. 2002. PMID: 12181315 Free article.

4

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Kayed R, et al. Science. 2003 Apr 18;300(5618):486-9. doi: 10.1126/science.1079469. Science. 2003. PMID: 12702875

5

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.

Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG. Kayed R, et al. J Biol Chem. 2004 Nov 5;279(45):46363-6. doi: 10.1074/jbc.C400260200. Epub 2004 Sep 21. J Biol Chem. 2004. PMID: 15385542 Free article.

6

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Yang F, et al. Among authors: kayed r. J Biol Chem. 2005 Feb 18;280(7):5892-901. doi: 10.1074/jbc.M404751200. Epub 2004 Dec 7. J Biol Chem. 2005. PMID: 15590663 Free article.

7

Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain.

Kokubo H, Kayed R, Glabe CG, Yamaguchi H. Kokubo H, et al. Among authors: kayed r. Brain Res. 2005 Jan 21;1031(2):222-8. doi: 10.1016/j.brainres.2004.10.041. Brain Res. 2005. PMID: 15649447

8

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.

Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Demuro A, et al. Among authors: kayed r. J Biol Chem. 2005 Apr 29;280(17):17294-300. doi: 10.1074/jbc.M500997200. Epub 2005 Feb 17. J Biol Chem. 2005. PMID: 15722360 Free article.

9

Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.

Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H. Kokubo H, et al. Among authors: kayed r. Brain Res. 2005 May 31;1045(1-2):224-8. doi: 10.1016/j.brainres.2005.03.017. Epub 2005 Apr 25. Brain Res. 2005. PMID: 15910781

10

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.

Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe CG, Kayed R, Robbins J. Sanbe A, et al. Among authors: kayed r. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13592-7. doi: 10.1073/pnas.0503324102. Epub 2005 Sep 9. Proc Natl Acad Sci U S A. 2005. PMID: 16155124 Free PMC article.

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