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Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A, Le Meur M, Roques BP, Maldonado R, Kieffer BL. Simonin F, et al. Among authors: kieffer bl. EMBO J. 1998 Feb 16;17(4):886-97. doi: 10.1093/emboj/17.4.886. EMBO J. 1998. PMID: 9463367 Free PMC article.
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
Matthes HW, Smadja C, Valverde O, Vonesch JL, Foutz AS, Boudinot E, Denavit-Saubié M, Severini C, Negri L, Roques BP, Maldonado R, Kieffer BL. Matthes HW, et al. Among authors: kieffer bl. J Neurosci. 1998 Sep 15;18(18):7285-95. doi: 10.1523/JNEUROSCI.18-18-07285.1998. J Neurosci. 1998. PMID: 9736649 Free PMC article.
301 results