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Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Wan ZL, Xu B, Chu YC, Katsoyannis PG, Weiss MA. Wan ZL, et al. Among authors: xu b. Biochemistry. 2003 Nov 11;42(44):12770-83. doi: 10.1021/bi034430o. Biochemistry. 2003. PMID: 14596591
Surprisingly, the core of the R-state is similar to that observed in solution nuclear magnetic resonance (NMR) studies of an engineered T-like monomer containing the same chiral substitution (allo-Ile(A2)-DKP-insulin; Xu, B., Hua, Q. X., Nakagawa, S. H., Jia, W., Ch …
Surprisingly, the core of the R-state is similar to that observed in solution nuclear magnetic resonance (NMR) studies of an engineered T-li …
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