Zhu M - Search Results

1

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery.

Fura A, Shu YZ, Zhu M, Hanson RL, Roongta V, Humphreys WG. Fura A, et al. Among authors: zhu m. J Med Chem. 2004 Aug 26;47(18):4339-51. doi: 10.1021/jm040066v. J Med Chem. 2004. PMID: 15317447 Review. No abstract available.

2

Drug metabolite profiling and identification by high-resolution mass spectrometry.

Zhu M, Zhang H, Humphreys WG. Zhu M, et al. J Biol Chem. 2011 Jul 22;286(29):25419-25. doi: 10.1074/jbc.R110.200055. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632546 Free PMC article. Review.

3

Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data.

Zhu M, Ma L, Zhang D, Ray K, Zhao W, Humphreys WG, Skiles G, Sanders M, Zhang H. Zhu M, et al. Drug Metab Dispos. 2006 Oct;34(10):1722-33. doi: 10.1124/dmd.106.009241. Epub 2006 Jun 30. Drug Metab Dispos. 2006. PMID: 16815965

4

Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.

Zheng J, Ma L, Xin B, Olah T, Humphreys WG, Zhu M. Zheng J, et al. Among authors: zhu m. Chem Res Toxicol. 2007 May;20(5):757-66. doi: 10.1021/tx600277y. Epub 2007 Apr 3. Chem Res Toxicol. 2007. PMID: 17402749

5

Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.

Zhu M, Ma L, Zhang H, Humphreys WG. Zhu M, et al. Anal Chem. 2007 Nov 1;79(21):8333-41. doi: 10.1021/ac071119u. Epub 2007 Oct 6. Anal Chem. 2007. PMID: 17918967

6

Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer.

Yao M, Ma L, Humphreys WG, Zhu M. Yao M, et al. Among authors: zhu m. J Mass Spectrom. 2008 Oct;43(10):1364-75. doi: 10.1002/jms.1412. J Mass Spectrom. 2008. PMID: 18416441

7

Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein.

Ruan Q, Ji QC, Arnold ME, Humphreys WG, Zhu M. Ruan Q, et al. Among authors: zhu m. Anal Chem. 2011 Dec 1;83(23):8937-44. doi: 10.1021/ac201540t. Epub 2011 Nov 1. Anal Chem. 2011. PMID: 21970614

8

Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.

Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG. Zhang D, et al. Among authors: zhu m. Drug Metab Dispos. 2007 Jan;35(1):139-49. doi: 10.1124/dmd.106.011932. Epub 2006 Oct 24. Drug Metab Dispos. 2007. PMID: 17062778

9

In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans.

Obermeier M, Yao M, Khanna A, Koplowitz B, Zhu M, Li W, Komoroski B, Kasichayanula S, Discenza L, Washburn W, Meng W, Ellsworth BA, Whaley JM, Humphreys WG. Obermeier M, et al. Among authors: zhu m. Drug Metab Dispos. 2010 Mar;38(3):405-14. doi: 10.1124/dmd.109.029165. Epub 2009 Dec 8. Drug Metab Dispos. 2010. PMID: 19996149 Clinical Trial.

10

Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats.

Zhang D, Ogan M, Gedamke R, Roongta V, Dai R, Zhu M, Rinehart JK, Klunk L, Mitroka J. Zhang D, et al. Among authors: zhu m. Drug Metab Dispos. 2003 Jul;31(7):837-45. doi: 10.1124/dmd.31.7.837. Drug Metab Dispos. 2003. PMID: 12814959

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