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In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.
Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P. Barbuch RJ, et al. Among authors: kulanthaivel p. Drug Metab Dispos. 2006 Feb;34(2):213-24. doi: 10.1124/dmd.105.007401. Epub 2005 Oct 28. Drug Metab Dispos. 2006. PMID: 16258078
Selective metabolism of vincristine in vitro by CYP3A5.
Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD. Dennison JB, et al. Among authors: kulanthaivel p. Drug Metab Dispos. 2006 Aug;34(8):1317-27. doi: 10.1124/dmd.106.009902. Epub 2006 May 5. Drug Metab Dispos. 2006. PMID: 16679390
Biosynthesis of drug glucuronides for use as authentic standards.
Soars MG, Mattiuz EL, Jackson DA, Kulanthaivel P, Ehlhardt WJ, Wrighton SA. Soars MG, et al. Among authors: kulanthaivel p. J Pharmacol Toxicol Methods. 2002 May-Jun;47(3):161-8. doi: 10.1016/S1056-8719(02)00231-9. J Pharmacol Toxicol Methods. 2002. PMID: 12628307
Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis.
Zmijewski M, Gillespie TA, Jackson DA, Schmidt DF, Yi P, Kulanthaivel P. Zmijewski M, et al. Among authors: kulanthaivel p. Drug Metab Dispos. 2006 Jun;34(6):925-31. doi: 10.1124/dmd.106.009522. Epub 2006 Feb 28. Drug Metab Dispos. 2006. PMID: 16507647
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Zamek-Gliszczynski MJ, Abraham TL, Alberts JJ, Kulanthaivel P, Jackson KA, Chow KH, McCann DJ, Hu H, Anderson S, Furr NA, Barbuch RJ, Cassidy KC. Zamek-Gliszczynski MJ, et al. Among authors: kulanthaivel p. Drug Metab Dispos. 2013 Apr;41(4):714-26. doi: 10.1124/dmd.112.048488. Epub 2013 Jan 10. Drug Metab Dispos. 2013. PMID: 23305709 Clinical Trial.
56 results