McKerrow JH - Search Results

1

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. J Biol Chem. 2004 Nov 12;279(46):48426-33. doi: 10.1074/jbc.M402470200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326171 Free article.

2

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Greenbaum DC, et al. Among authors: mckerrow jh. J Med Chem. 2004 Jun 3;47(12):3212-9. doi: 10.1021/jm030549j. J Med Chem. 2004. PMID: 15163200

3

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. Among authors: mckerrow jh. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

4

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. Abdulla MH, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298. PLoS Negl Trop Dis. 2008. PMID: 18820745 Free PMC article.

5

High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.

Mackey ZB, Koupparis K, Nishino M, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. Chem Biol Drug Des. 2011 Sep;78(3):454-63. doi: 10.1111/j.1747-0285.2011.01156.x. Epub 2011 Jul 14. Chem Biol Drug Des. 2011. PMID: 21668652 Free PMC article.

6

Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase.

Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Sajid M, et al. Among authors: mckerrow jh. Mol Biochem Parasitol. 2003 Sep;131(1):65-75. doi: 10.1016/s0166-6851(03)00194-4. Mol Biochem Parasitol. 2003. PMID: 12967713

7

Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.

Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: mckerrow jh. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423

8

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.

Mackey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. Mackey ZB, et al. Among authors: mckerrow jh. Chem Biol Drug Des. 2006 May;67(5):355-63. doi: 10.1111/j.1747-0285.2006.00389.x. Chem Biol Drug Des. 2006. PMID: 16784460

9

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: mckerrow jh. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

10

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Chen CK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. PLoS Negl Trop Dis. 2009. PMID: 19190730 Free PMC article.

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