Smith ND - Search Results

1

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND. Roppe J, et al. Among authors: smith nd. J Med Chem. 2004 Sep 9;47(19):4645-8. doi: 10.1021/jm049828c. J Med Chem. 2004. PMID: 15341479

2

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. Cosford ND, et al. Among authors: smith nd. J Med Chem. 2003 Jan 16;46(2):204-6. doi: 10.1021/jm025570j. J Med Chem. 2003. PMID: 12519057

3

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND. Huang D, et al. Among authors: smith nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6. doi: 10.1016/j.bmcl.2004.09.012. Bioorg Med Chem Lett. 2004. PMID: 15482906

4

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND. Poon SF, et al. Among authors: smith nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5477-80. doi: 10.1016/j.bmcl.2004.09.011. Bioorg Med Chem Lett. 2004. PMID: 15482907

5

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.

Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND. Smith ND, et al. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5481-4. doi: 10.1016/j.bmcl.2004.09.018. Bioorg Med Chem Lett. 2004. PMID: 15482908

6

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.

Tehrani LR, Smith ND, Huang D, Poon SF, Roppe JR, Seiders TJ, Chapman DF, Chung J, Cramer M, Cosford ND. Tehrani LR, et al. Among authors: smith nd. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5061-4. doi: 10.1016/j.bmcl.2005.07.062. Epub 2005 Sep 23. Bioorg Med Chem Lett. 2005. PMID: 16183275

7

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology.

Eastman B, Chen C, Smith ND, Poon S, Chung J, Reyes-Manalo G, Cosford ND, Munoz B. Eastman B, et al. Among authors: smith nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5485-8. doi: 10.1016/j.bmcl.2004.09.016. Bioorg Med Chem Lett. 2004. PMID: 15482909

8

Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Bonnefous C, et al. Among authors: smith nd. J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b. J Med Chem. 2009. PMID: 19374401

9

One-step synthesis of 3-aryl- and 3,4-diaryl-(1H)-pyrroles using tosylmethyl isocyanide (TOSMIC).

Smith ND, Huang D, Cosford ND. Smith ND, et al. Org Lett. 2002 Oct 3;4(20):3537-9. doi: 10.1021/ol0267073. Org Lett. 2002. PMID: 12323063

10

Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.

Poon SF, Stock N, Payne JE, McGuire AR, Stearns B, Yang X, Chen W, Munoz B, Smith ND. Poon SF, et al. Among authors: smith nd. Bioorg Med Chem Lett. 2005 May 2;15(9):2259-63. doi: 10.1016/j.bmcl.2005.03.009. Bioorg Med Chem Lett. 2005. PMID: 15837305

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