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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.
Stone RM, DeAngelo DJ, Klimek V, Galinsky I, Estey E, Nimer SD, Grandin W, Lebwohl D, Wang Y, Cohen P, Fox EA, Neuberg D, Clark J, Gilliland DG, Griffin JD. Stone RM, et al. Among authors: gilliland dg. Blood. 2005 Jan 1;105(1):54-60. doi: 10.1182/blood-2004-03-0891. Epub 2004 Sep 2. Blood. 2005. PMID: 15345597 Free article. Clinical Trial.
Role of FLT3 in leukemia.
Gilliland DG, Griffin JD. Gilliland DG, et al. Curr Opin Hematol. 2002 Jul;9(4):274-81. doi: 10.1097/00062752-200207000-00003. Curr Opin Hematol. 2002. PMID: 12042700 Review.
The roles of FLT3 in hematopoiesis and leukemia.
Gilliland DG, Griffin JD. Gilliland DG, et al. Blood. 2002 Sep 1;100(5):1532-42. doi: 10.1182/blood-2002-02-0492. Blood. 2002. PMID: 12176867 Free article. Review.
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML.
Jiang J, Paez JG, Lee JC, Bo R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, Gilliland DG, Meyerson M, Sellers WR. Jiang J, et al. Among authors: gilliland dg. Blood. 2004 Sep 15;104(6):1855-8. doi: 10.1182/blood-2004-02-0712. Epub 2004 Jun 3. Blood. 2004. PMID: 15178581 Free article.
Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.
Gotlib J, Berubé C, Growney JD, Chen CC, George TI, Williams C, Kajiguchi T, Ruan J, Lilleberg SL, Durocher JA, Lichy JH, Wang Y, Cohen PS, Arber DA, Heinrich MC, Neckers L, Galli SJ, Gilliland DG, Coutré SE. Gotlib J, et al. Among authors: gilliland dg. Blood. 2005 Oct 15;106(8):2865-70. doi: 10.1182/blood-2005-04-1568. Epub 2005 Jun 21. Blood. 2005. PMID: 15972446 Free PMC article.
275 results