Bottomley SP - Search Results

1

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. J Biol Chem. 2004 Nov 12;279(46):47643-51. doi: 10.1074/jbc.M405799200. Epub 2004 Sep 1. J Biol Chem. 2004. PMID: 15345714 Free article.

2

Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.

Chow MK, Paulson HL, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. J Mol Biol. 2004 Jan 2;335(1):333-41. doi: 10.1016/j.jmb.2003.08.064. J Mol Biol. 2004. PMID: 14659761

3

Promiscuous beta-strand interactions and the conformational diseases.

Chow MK, Lomas DA, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. Curr Med Chem. 2004 Feb;11(4):491-9. doi: 10.2174/0929867043455936. Curr Med Chem. 2004. PMID: 14965229 Review.

4

The role of protein misfolding in the pathogenesis of human diseases.

Ellisdon AM, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. IUBMB Life. 2004 Mar;56(3):119-23. doi: 10.1080/15216540410001674003. IUBMB Life. 2004. PMID: 15185744 Free article. Review.

5

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3.

Chow MK, Mackay JP, Whisstock JC, Scanlon MJ, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. Biochem Biophys Res Commun. 2004 Sep 17;322(2):387-94. doi: 10.1016/j.bbrc.2004.07.131. Biochem Biophys Res Commun. 2004. PMID: 15325242

6

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.

Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J, Whisstock JC. Fulton KF, et al. Among authors: bottomley sp. J Biol Chem. 2005 Mar 4;280(9):8435-42. doi: 10.1074/jbc.M410206200. Epub 2004 Dec 7. J Biol Chem. 2005. PMID: 15590653 Free article.

7

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

Ellisdon AM, Thomas B, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. J Biol Chem. 2006 Jun 23;281(25):16888-16896. doi: 10.1074/jbc.M601470200. Epub 2006 Apr 19. J Biol Chem. 2006. PMID: 16624810 Free article.

8

Purification of polyglutamine proteins.

Chow MK, Ellisdon AM, Cabrita LD, Bottomley SP. Chow MK, et al. Among authors: bottomley sp. Methods Enzymol. 2006;413:1-19. doi: 10.1016/S0076-6879(06)13001-3. Methods Enzymol. 2006. PMID: 17046388

9

Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.

Ellisdon AM, Pearce MC, Bottomley SP. Ellisdon AM, et al. Among authors: bottomley sp. J Mol Biol. 2007 Apr 27;368(2):595-605. doi: 10.1016/j.jmb.2007.02.058. Epub 2007 Feb 22. J Mol Biol. 2007. PMID: 17362987

10

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding.

Pearce MC, Cabrita LD, Ellisdon AM, Bottomley SP. Pearce MC, et al. Among authors: bottomley sp. FEBS J. 2007 Jul;274(14):3622-3632. doi: 10.1111/j.1742-4658.2007.05897.x. Epub 2007 Jul 3. FEBS J. 2007. PMID: 17608807 Free article.

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