Lodge NJ - Search Results

1

4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle.

Hewawasam P, Fan W, Cook DA, Newberry KS, Boissard CG, Gribkoff VK, Starrett J, Lodge NJ. Hewawasam P, et al. Among authors: lodge nj. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4479-82. doi: 10.1016/j.bmcl.2004.06.051. Bioorg Med Chem Lett. 2004. PMID: 15357975

2

Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.

Sivarao DV, Newberry K, Langdon S, Lee AV, Hewawasam P, Plym MJ, Signor L, Myers R, Lodge NJ. Sivarao DV, et al. Among authors: lodge nj. J Pharmacol Exp Ther. 2005 May;313(2):840-7. doi: 10.1124/jpet.104.079285. Epub 2005 Feb 8. J Pharmacol Exp Ther. 2005. PMID: 15701710

3

4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.

Hewawasam P, Fan W, Ding M, Flint K, Cook D, Goggins GD, Myers RA, Gribkoff VK, Boissard CG, Dworetzky SI, Starrett JE Jr, Lodge NJ. Hewawasam P, et al. Among authors: lodge nj. J Med Chem. 2003 Jul 3;46(14):2819-22. doi: 10.1021/jm030005h. J Med Chem. 2003. PMID: 12825925

4

Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes.

Vrudhula VM, Dasgupta B, Boissard CG, Gribkoff VK, Santone KS, Dalterio RA, Lodge NJ, Starrett JE Jr. Vrudhula VM, et al. Among authors: lodge nj. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4286-90. doi: 10.1016/j.bmcl.2005.06.056. Bioorg Med Chem Lett. 2005. PMID: 16061379

5

The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.

Hewawasam P, Erway M, Thalody G, Weiner H, Boissard CG, Gribkoff VK, Meanwell NA, Lodge N, Starrett JE Jr. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1117-20. doi: 10.1016/s0960-894x(02)00099-9. Bioorg Med Chem Lett. 2002. PMID: 11909730

6

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.

Boy KM, Guernon JM, Sit SY, Xie K, Hewawasam P, Boissard CG, Dworetzky SI, Natale J, Gribkoff VK, Lodge N, Starrett JE Jr. Boy KM, et al. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5089-93. doi: 10.1016/j.bmcl.2004.07.080. Bioorg Med Chem Lett. 2004. PMID: 15380205

7

Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat.

Sivarao DV, Newberry K, Lodge NJ. Sivarao DV, et al. Among authors: lodge nj. Eur J Pharmacol. 2004 Jun 21;494(1):23-9. doi: 10.1016/j.ejphar.2004.04.034. Eur J Pharmacol. 2004. PMID: 15194447

8

NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the gerbil forced swim test.

Lelas S, Li YW, Wallace-Boone TL, Taber MT, Newton AE, Pieschl RL, Davis CD, Molski TF, Newberry KS, Parker MF, Gillman KW, Bronson JJ, Macor JE, Lodge NJ. Lelas S, et al. Among authors: lodge nj. Neuropharmacology. 2013 Oct;73:232-40. doi: 10.1016/j.neuropharm.2013.05.038. Epub 2013 Jun 12. Neuropharmacology. 2013. PMID: 23770339

9

Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels.

Gentles RG, Grant-Young K, Hu S, Huang Y, Poss MA, Andres C, Fiedler T, Knox R, Lodge N, Weaver CD, Harden DG. Gentles RG, et al. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5316-9. doi: 10.1016/j.bmcl.2008.08.023. Epub 2008 Aug 14. Bioorg Med Chem Lett. 2008. PMID: 18774291

10

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, Dickinson KE. Atwal KS, et al. Among authors: lodge nj. J Med Chem. 1998 Jan 29;41(3):271-5. doi: 10.1021/jm970762d. J Med Chem. 1998. PMID: 9464357 No abstract available.

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