Jakes S - Search Results

1

Discovery and characterization of a substrate selective p38alpha inhibitor.

Davidson W, Frego L, Peet GW, Kroe RR, Labadia ME, Lukas SM, Snow RJ, Jakes S, Grygon CA, Pargellis C, Werneburg BG. Davidson W, et al. Among authors: jakes s. Biochemistry. 2004 Sep 21;43(37):11658-71. doi: 10.1021/bi0495073. Biochemistry. 2004. PMID: 15362850

2

Pim kinase substrate identification and specificity.

Peng C, Knebel A, Morrice NA, Li X, Barringer K, Li J, Jakes S, Werneburg B, Wang L. Peng C, et al. Among authors: jakes s. J Biochem. 2007 Mar;141(3):353-62. doi: 10.1093/jb/mvm040. Epub 2007 Jan 18. J Biochem. 2007. PMID: 17234686

3

Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor.

Labadia ME, Jakes S, Grygon CA, Greenwood DJ, Schembri-King J, Lukas SM, Warren TC, Ingraham RH. Labadia ME, et al. Among authors: jakes s. Arch Biochem Biophys. 1997 Jun 1;342(1):117-25. doi: 10.1006/abbi.1997.0118. Arch Biochem Biophys. 1997. PMID: 9185620

4

Discovery of 2-phenylamino-imidazo[4,5-h]isoquinolin-9-ones: a new class of inhibitors of lck kinase.

Snow RJ, Cardozo MG, Morwick TM, Busacca CA, Dong Y, Eckner RJ, Jacober S, Jakes S, Kapadia S, Lukas S, Panzenbeck M, Peet GW, Peterson JD, Prokopowicz AS 3rd, Sellati R, Tolbert RM, Tschantz MA, Moss N. Snow RJ, et al. Among authors: jakes s. J Med Chem. 2002 Aug 1;45(16):3394-405. doi: 10.1021/jm020113o. J Med Chem. 2002. PMID: 12139450

5

Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.

Goldberg DR, Butz T, Cardozo MG, Eckner RJ, Hammach A, Huang J, Jakes S, Kapadia S, Kashem M, Lukas S, Morwick TM, Panzenbeck M, Patel U, Pav S, Peet GW, Peterson JD, Prokopowicz AS 3rd, Snow RJ, Sellati R, Takahashi H, Tan J, Tschantz MA, Wang XJ, Wang Y, Wolak J, Xiong P, Moss N. Goldberg DR, et al. Among authors: jakes s. J Med Chem. 2003 Apr 10;46(8):1337-49. doi: 10.1021/jm020446l. J Med Chem. 2003. PMID: 12672234

6

Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.

Kashem MA, Nelson RM, Yingling JD, Pullen SS, Prokopowicz AS 3rd, Jones JW, Wolak JP, Rogers GR, Morelock MM, Snow RJ, Homon CA, Jakes S. Kashem MA, et al. Among authors: jakes s. J Biomol Screen. 2007 Feb;12(1):70-83. doi: 10.1177/1087057106296047. Epub 2006 Dec 8. J Biomol Screen. 2007. PMID: 17166826

7

Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.

Li J, Peet GW, Pullen SS, Schembri-King J, Warren TC, Marcu KB, Kehry MR, Barton R, Jakes S. Li J, et al. Among authors: jakes s. J Biol Chem. 1998 Nov 13;273(46):30736-41. doi: 10.1074/jbc.273.46.30736. J Biol Chem. 1998. PMID: 9804849 Free article.

8

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway.

Tatake RJ, O'Neill MM, Kennedy CA, Wayne AL, Jakes S, Wu D, Kugler SZ Jr, Kashem MA, Kaplita P, Snow RJ. Tatake RJ, et al. Among authors: jakes s. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. doi: 10.1016/j.bbrc.2008.09.087. Epub 2008 Oct 1. Biochem Biophys Res Commun. 2008. PMID: 18834865

9

Binding affinities of the SH2 domains of ZAP-70, p56lck and Shc to the zeta chain ITAMs of the T-cell receptor determined by surface plasmon resonance.

Labadia ME, Ingraham RH, Schembri-King J, Morelock MM, Jakes S. Labadia ME, et al. Among authors: jakes s. J Leukoc Biol. 1996 May;59(5):740-6. J Leukoc Biol. 1996. PMID: 8656061

10

Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.

Tong L, Warren TC, Lukas S, Schembri-King J, Betageri R, Proudfoot JR, Jakes S. Tong L, et al. Among authors: jakes s. J Biol Chem. 1998 Aug 7;273(32):20238-42. doi: 10.1074/jbc.273.32.20238. J Biol Chem. 1998. PMID: 9685372 Free article.

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