Clingen PH - Search Results

1

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA, Spanswick VJ, Brooks N, Clingen PH, McHugh PJ, Hochhauser D, Pedley RB, Kelland LR, Alley MC, Schultz R, Hollingshead MG, Schweikart KM, Tomaszewski JE, Sausville EA, Gregson SJ, Howard PW, Thurston DE. Hartley JA, et al. Among authors: clingen ph. Cancer Res. 2004 Sep 15;64(18):6693-9. doi: 10.1158/0008-5472.CAN-03-2941. Cancer Res. 2004. PMID: 15374986

2

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.

De Silva IU, McHugh PJ, Clingen PH, Hartley JA. De Silva IU, et al. Among authors: clingen ph. Nucleic Acids Res. 2002 Sep 1;30(17):3848-56. doi: 10.1093/nar/gkf479. Nucleic Acids Res. 2002. PMID: 12202770 Free PMC article.

3

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.

Clingen PH, De Silva IU, McHugh PJ, Ghadessy FJ, Tilby MJ, Thurston DE, Hartley JA. Clingen PH, et al. Nucleic Acids Res. 2005 Jun 8;33(10):3283-91. doi: 10.1093/nar/gki639. Print 2005. Nucleic Acids Res. 2005. PMID: 15944449 Free PMC article.

4

Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links.

Clingen PH, Arlett CF, Hartley JA, Parris CN. Clingen PH, et al. Exp Cell Res. 2007 Feb 15;313(4):753-60. doi: 10.1016/j.yexcr.2006.11.007. Epub 2006 Nov 18. Exp Cell Res. 2007. PMID: 17188678

5

Phase I study of sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors.

Hochhauser D, Meyer T, Spanswick VJ, Wu J, Clingen PH, Loadman P, Cobb M, Gumbrell L, Begent RH, Hartley JA, Jodrell D. Hochhauser D, et al. Among authors: clingen ph. Clin Cancer Res. 2009 Mar 15;15(6):2140-7. doi: 10.1158/1078-0432.CCR-08-1315. Epub 2009 Mar 10. Clin Cancer Res. 2009. PMID: 19276288 Clinical Trial.

6

γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from 2 phase I clinical trials of SJG-136 (SG2000).

Wu J, Clingen PH, Spanswick VJ, Mellinas-Gomez M, Meyer T, Puzanov I, Jodrell D, Hochhauser D, Hartley JA. Wu J, et al. Among authors: clingen ph. Clin Cancer Res. 2013 Feb 1;19(3):721-30. doi: 10.1158/1078-0432.CCR-12-2529. Epub 2012 Dec 18. Clin Cancer Res. 2013. PMID: 23251007 Free PMC article.

7

Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells.

De Silva IU, McHugh PJ, Clingen PH, Hartley JA. De Silva IU, et al. Among authors: clingen ph. Mol Cell Biol. 2000 Nov;20(21):7980-90. doi: 10.1128/MCB.20.21.7980-7990.2000. Mol Cell Biol. 2000. PMID: 11027268 Free PMC article.

8

Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy.

Clingen PH, Wu JY, Miller J, Mistry N, Chin F, Wynne P, Prise KM, Hartley JA. Clingen PH, et al. Biochem Pharmacol. 2008 Jul 1;76(1):19-27. doi: 10.1016/j.bcp.2008.03.025. Epub 2008 Apr 16. Biochem Pharmacol. 2008. PMID: 18508035

9

Induction of cyclobutane pyrimidine dimers, pyrimidine(6-4)pyrimidone photoproducts, and Dewar valence isomers by natural sunlight in normal human mononuclear cells.

Clingen PH, Arlett CF, Roza L, Mori T, Nikaido O, Green MH. Clingen PH, et al. Cancer Res. 1995 Jun 1;55(11):2245-8. Cancer Res. 1995. PMID: 7757971

10

The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.

Berneburg M, Clingen PH, Harcourt SA, Lowe JE, Taylor EM, Green MH, Krutmann J, Arlett CF, Lehmann AR. Berneburg M, et al. Among authors: clingen ph. Cancer Res. 2000 Jan 15;60(2):431-8. Cancer Res. 2000. PMID: 10667598

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