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Page 1
Phase II study of irinotecan (CPT-11) administered every 2 weeks as treatment for patients with colorectal cancer resistant to previous treatment with 5-fluorouracil-based therapies: comparison of two different dose schedules (250 and 200 mg/m2) according to toxicity prognostic factors.
Saigi E, Salut A, Campos JM, Losa F, Manzano H, Batiste-Alentorn E, Acusa A, Vélez de Mendizabal E, Guasch I, Antón I; ACROSS Cooperative Group. Saigi E, et al. Among authors: manzano h. Anticancer Drugs. 2004 Oct;15(9):835-41. doi: 10.1097/00001813-200410000-00003. Anticancer Drugs. 2004. PMID: 15457123 Clinical Trial.
Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer.
Nogué M, Salud A, Batiste-Alentorn E, Saigí E, Losa F, Cirera L, Méndez M, Campos JM, Galan A, Escudero P, Arcusa A, Manzano H, de Mendizábal EV, de Olaguer JP, Boleda M, Guasch I, Vicente P. Nogué M, et al. Among authors: manzano h. Eur J Cancer. 2005 Oct;41(15):2241-9. doi: 10.1016/j.ejca.2005.07.013. Eur J Cancer. 2005. PMID: 16214045 Clinical Trial.
First-Line Biological Agents Plus Chemotherapy in Older Patients with Metastatic Colorectal Cancer: A Retrospective Pooled Analysis.
García-Alfonso P, Díaz-Rubio E, Abad A, Carrato A, Massutí B, Ortiz-Morales MJ, Manzano Mozo JL, Muñoz A, Durán G, Sastre J, Safont MJ, Ferreiro R, Rivera F, González E, Valladares-Ayerbes M, Grávalos C, Alonso-Orduña V, Viéitez JM, Yubero A, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD). García-Alfonso P, et al. Drugs Aging. 2021 Mar;38(3):219-231. doi: 10.1007/s40266-021-00834-w. Epub 2021 Feb 22. Drugs Aging. 2021. PMID: 33615402 Free PMC article.
Role of Kras status in patients with metastatic colorectal cancer receiving first-line chemotherapy plus bevacizumab: a TTD group cooperative study.
Díaz-Rubio E, Gómez-España A, Massutí B, Sastre J, Reboredo M, Manzano JL, Rivera F, Safont MJ, Montagut C, González E, Benavides M, Marcuello E, Cervantes A, Martínez de Prado P, Fernández-Martos C, Arrivi A, Bando I, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD). Díaz-Rubio E, et al. PLoS One. 2012;7(10):e47345. doi: 10.1371/journal.pone.0047345. Epub 2012 Oct 12. PLoS One. 2012. PMID: 23174912 Free PMC article. Clinical Trial.
Diagnosis delay and follow-up strategies in colorectal cancer. Prognosis implications: a study protocol.
Pita Fernández S, Pértega Díaz S, López Calviño B, González Santamaría P, Seoane Pillado T, Arnal Monreal F, Maciá F, Sánchez Calavera MA, Espí Macías A, Valladares Ayerbes M, Pazos A, Reboredo López M, González Saez L, Montserrat MR, Segura Noguera JM, Monreal Aliaga I, González Luján L, Martín Rabadán M, Murta Nascimento C, Pueyo O, Boscá Watts MM, Cabeza Irigoyen E, Casmitjana Abella M, Pinilla M, Costa Alcaraz A, Ruiz Torrejón A, Burón Pust A, García Aranda C, de Lluc Bennasar M, Lafita Mainz S, Novella M, Manzano H, Vadell C, Falcó E, Esteva M. Pita Fernández S, et al. Among authors: manzano h. BMC Cancer. 2010 Oct 5;10:528. doi: 10.1186/1471-2407-10-528. BMC Cancer. 2010. PMID: 20920369 Free PMC article.
Influence of BRAF and PIK3CA mutations on the efficacy of FOLFIRI plus bevacizumab or cetuximab as first-line therapy in patients with RAS wild-type metastatic colorectal carcinoma and <3 baseline circulating tumour cells: the randomised phase II VISNÚ-2 study.
Sastre J, García-Alfonso P, Viéitez JM, Cano MT, Rivera F, Reina-Zoilo JJ, Salud-Salvia A, Quintero G, Robles-Díaz L, Safont MJ, La Casta A, Gil S, Polo E, Asensio-Martínez E, García-Paredes B, López RL, Guillot M, Valladares-Ayerbes M, Aranda E, Díaz-Rubio E; Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD). Sastre J, et al. ESMO Open. 2021 Apr;6(2):100062. doi: 10.1016/j.esmoop.2021.100062. Epub 2021 Mar 10. ESMO Open. 2021. PMID: 33711671 Free PMC article. Clinical Trial.
Phase I trial of oxaliplatin in combination with cisplatin, protacted-infusion fluorouracil, and radiotherapy in advanced esophageal and gastroesophageal carcinoma.
Maurel J, Cervantes A, Conill C, Salazar R, Martin-Richard M, Pera M, Manzano H, Chirivella I, Gallego R, Marfa X. Maurel J, et al. Among authors: manzano h. Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):91-6. doi: 10.1016/j.ijrobp.2004.09.009. Int J Radiat Oncol Biol Phys. 2005. PMID: 15850907 Clinical Trial.
Factors related with symptom duration until diagnosis and treatment of symptomatic colorectal cancer.
Esteva M, Leiva A, Ramos M, Pita-Fernández S, González-Luján L, Casamitjana M, Sánchez MA, Pértega-Díaz S, Ruiz A, Gonzalez-Santamaría P, Martín-Rabadán M, Costa-Alcaraz AM, Espí A, Macià F, Segura JM, Lafita S, Arnal-Monreal F, Amengual I, Boscá-Watts MM, Hospital A, Manzano H, Magallón R; DECCIRE GROUP. Esteva M, et al. Among authors: manzano h. BMC Cancer. 2013 Feb 23;13:87. doi: 10.1186/1471-2407-13-87. BMC Cancer. 2013. PMID: 23432789 Free PMC article.
Prospective Biomarker Study in Advanced RAS Wild-Type Colorectal Cancer: POSIBA Trial (GEMCAD 10-02).
García-Albéniz X, Alonso V, Escudero P, Méndez M, Gallego J, Rodríguez JR, Salud A, Fernández-Plana J, Manzano H, Zanui M, Falcó E, Feliu J, Gil M, Fernández-Martos C, Bohn U, Alonso C, Calderero V, Rojo F, Cuatrecasas M, Maurel J. García-Albéniz X, et al. Among authors: manzano h. Oncologist. 2019 Nov;24(11):e1115-e1122. doi: 10.1634/theoncologist.2018-0728. Epub 2019 Jun 24. Oncologist. 2019. PMID: 31235483 Free PMC article. Clinical Trial.
Metastatic Colorectal Cancer. First Line Therapy for Unresectable Disease.
Aparicio J, Esposito F, Serrano S, Falco E, Escudero P, Ruiz-Casado A, Manzano H, Fernandez-Montes A. Aparicio J, et al. Among authors: manzano h. J Clin Med. 2020 Nov 30;9(12):3889. doi: 10.3390/jcm9123889. J Clin Med. 2020. PMID: 33265959 Free PMC article. Review.
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