Komander D - Search Results

1

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Komander D, et al. EMBO J. 2004 Oct 13;23(20):3918-28. doi: 10.1038/sj.emboj.7600379. Epub 2004 Sep 30. EMBO J. 2004. PMID: 15457207 Free PMC article.

2

Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes.

van Tol BDM, van Doodewaerd BR, Lageveen-Kammeijer GSM, Jansen BC, Talavera Ormeño CMP, Hekking PJM, Sapmaz A, Kim RQ, Moutsiopoulou A, Komander D, Wuhrer M, van der Heden van Noort GJ, Ovaa H, Geurink PP. van Tol BDM, et al. Among authors: komander d. Nat Commun. 2023 Mar 25;14(1):1661. doi: 10.1038/s41467-023-37363-6. Nat Commun. 2023. PMID: 36966155 Free PMC article.

3

Deubiquitinases in cancer.

Dewson G, Eichhorn PJA, Komander D. Dewson G, et al. Among authors: komander d. Nat Rev Cancer. 2023 Dec;23(12):842-862. doi: 10.1038/s41568-023-00633-y. Epub 2023 Nov 7. Nat Rev Cancer. 2023. PMID: 37935888 Review.

4

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii.

Wilde ML, Ruparel U, Klemm T, Lee VV, Calleja DJ, Komander D, Tonkin CJ. Wilde ML, et al. Among authors: komander d. Life Sci Alliance. 2023 Mar 23;6(6):e202201710. doi: 10.26508/lsa.202201710. Print 2023 Jun. Life Sci Alliance. 2023. PMID: 36958824 Free PMC article.

5

Structural insights into the catalytic mechanism of a family 18 exo-chitinase.

van Aalten DM, Komander D, Synstad B, Gåseidnes S, Peter MG, Eijsink VG. van Aalten DM, et al. Among authors: komander d. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8979-84. doi: 10.1073/pnas.151103798. Proc Natl Acad Sci U S A. 2001. PMID: 11481469 Free PMC article.

6

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.

Tabudravu JN, Eijsink VG, Gooday GW, Jaspars M, Komander D, Legg M, Synstad B, van Aalten DM. Tabudravu JN, et al. Among authors: komander d. Bioorg Med Chem. 2002 Apr;10(4):1123-8. doi: 10.1016/s0968-0896(01)00372-8. Bioorg Med Chem. 2002. PMID: 11836123

7

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM. Biondi RM, et al. Among authors: komander d. EMBO J. 2002 Aug 15;21(16):4219-28. doi: 10.1093/emboj/cdf437. EMBO J. 2002. PMID: 12169624 Free PMC article.

8

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

9

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

Komander D, Deak M, Morrice N, van Aalten DM. Komander D, et al. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):314-6. doi: 10.1107/S0907444903028518. Epub 2004 Jan 23. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 14747709

10

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.

Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM. Komander D, et al. Structure. 2004 Feb;12(2):215-26. doi: 10.1016/j.str.2004.01.005. Structure. 2004. PMID: 14962382 Free article.

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