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Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.
Hamzah HG, Pierce A, Stewart WA, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton AD. Hamzah HG, et al. Among authors: peter downes c. Leukemia. 2005 Oct;19(10):1851-3. doi: 10.1038/sj.leu.2403919. Leukemia. 2005. PMID: 16107888 No abstract available.