Osawa Y - Search Results

1

Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes.

Lowe ER, Everett AC, Lee AJ, Lau M, Dunbar AY, Berka V, Tsai AL, Osawa Y. Lowe ER, et al. Among authors: osawa y. Drug Metab Dispos. 2005 Jan;33(1):131-8. doi: 10.1124/dmd.104.001891. Epub 2004 Oct 6. Drug Metab Dispos. 2005. PMID: 15470159

2

hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

Billecke SS, Bender AT, Kanelakis KC, Murphy PJ, Lowe ER, Kamada Y, Pratt WB, Osawa Y. Billecke SS, et al. Among authors: osawa y. J Biol Chem. 2002 Jun 7;277(23):20504-9. doi: 10.1074/jbc.M201940200. Epub 2002 Mar 28. J Biol Chem. 2002. PMID: 11923316 Free article.

3

Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo.

Vuletich JL, Lowe ER, Jianmongkol S, Kamada Y, Kent UM, Bender AT, Demady DR, Hollenberg PF, Osawa Y. Vuletich JL, et al. Among authors: osawa y. Mol Pharmacol. 2002 Jul;62(1):110-8. doi: 10.1124/mol.62.1.110. Mol Pharmacol. 2002. PMID: 12065761

4

Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones.

Osawa Y, Lowe ER, Everett AC, Dunbar AY, Billecke SS. Osawa Y, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):493-7. doi: 10.1124/jpet.102.035055. J Pharmacol Exp Ther. 2003. PMID: 12538799 Review.

5

Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke.

Demady DR, Lowe ER, Everett AC, Billecke SS, Kamada Y, Dunbar AY, Osawa Y. Demady DR, et al. Among authors: osawa y. Drug Metab Dispos. 2003 Jul;31(7):932-7. doi: 10.1124/dmd.31.7.932. Drug Metab Dispos. 2003. PMID: 12814971

6

The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.

Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y. Billecke SS, et al. Among authors: osawa y. J Biol Chem. 2004 Jul 16;279(29):30252-8. doi: 10.1074/jbc.M403864200. Epub 2004 May 19. J Biol Chem. 2004. PMID: 15155759 Free article.

C., Murphy, P. J. M., Lowe, E. R., Kamada, Y., Pratt, W. B., and Osawa, Y. (2002) J. Biol. Chem. 278, 15465-15468). In this work, we examine heme binding by apo-nNOS to form the active enzyme in a cell-free system. ...

C., Murphy, P. J. M., Lowe, E. R., Kamada, Y., Pratt, W. B., and Osawa, Y. (2002) J. Biol. Chem. 278, 15465-15468). In …

7

Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis.

Dunbar AY, Kamada Y, Jenkins GJ, Lowe ER, Billecke SS, Osawa Y. Dunbar AY, et al. Among authors: osawa y. Mol Pharmacol. 2004 Oct;66(4):964-9. doi: 10.1124/mol.104.000125. Epub 2004 Jul 2. Mol Pharmacol. 2004. PMID: 15235101

8

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.

Peng HM, Morishima Y, Jenkins GJ, Dunbar AY, Lau M, Patterson C, Pratt WB, Osawa Y. Peng HM, et al. Among authors: osawa y. J Biol Chem. 2004 Dec 17;279(51):52970-7. doi: 10.1074/jbc.M406926200. Epub 2004 Oct 4. J Biol Chem. 2004. PMID: 15466472 Free article.

9

Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.

Kamada Y, Jenkins GJ, Lau M, Dunbar AY, Lowe ER, Osawa Y. Kamada Y, et al. Among authors: osawa y. Brain Res Mol Brain Res. 2005 Dec 7;142(1):19-27. doi: 10.1016/j.molbrainres.2005.09.003. Epub 2005 Oct 10. Brain Res Mol Brain Res. 2005. PMID: 16216381

10

Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group.

Lee AJ, Noon KR, Jianmongkol S, Lau M, Jenkins GJ, Osawa Y. Lee AJ, et al. Among authors: osawa y. Chem Res Toxicol. 2005 Dec;18(12):1927-33. doi: 10.1021/tx050263c. Chem Res Toxicol. 2005. PMID: 16359183 Free PMC article.

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