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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: hewitson ks. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. doi: 10.1073/pnas.0606877103. Epub 2006 Sep 26. Proc Natl Acad Sci U S A. 2006. PMID: 17003112 Free PMC article.
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Schlemminger I, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. doi: 10.1016/s0960-894x(03)00149-5. Bioorg Med Chem Lett. 2003. PMID: 12668010
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: hewitson ks. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ. Epstein AC, et al. Among authors: hewitson ks. Cell. 2001 Oct 5;107(1):43-54. doi: 10.1016/s0092-8674(01)00507-4. Cell. 2001. PMID: 11595184 Free article.
47 results