Schaddelee MP - Search Results

1

Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat.

Schaddelee MP, Dejongh J, Collins SD, de Boer AG, Ijzerman AP, Danhof M. Schaddelee MP, et al. Eur J Pharmacol. 2004 Nov 3;504(1-2):7-15. doi: 10.1016/j.ejphar.2004.09.029. Eur J Pharmacol. 2004. PMID: 15507215

2

Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists.

Schaddelee MP, Groenendaal D, DeJongh J, Cleypool CG, IJzerman AP, De Boer AG, Danhof M. Schaddelee MP, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1138-46. doi: 10.1124/jpet.104.071308. Epub 2004 Aug 3. J Pharmacol Exp Ther. 2004. PMID: 15292459

3

Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships.

Schaddelee MP, Voorwinden HL, Groenendaal D, Hersey A, Ijzerman AP, Danhof M, De Boer AG. Schaddelee MP, et al. Eur J Pharm Sci. 2003 Nov;20(3):347-56. doi: 10.1016/j.ejps.2003.08.003. Eur J Pharm Sci. 2003. PMID: 14592701

4

Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents.

Schaddelee MP, Read KD, Cleypool CG, Ijzerman AP, Danhof M, de Boer AG. Schaddelee MP, et al. Eur J Pharm Sci. 2005 Jan;24(1):59-66. doi: 10.1016/j.ejps.2004.09.010. Eur J Pharm Sci. 2005. PMID: 15626578

5

Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain.

Schaddelee MP, Collins SD, DeJongh J, de Boer AG, Ijzerman AP, Danhof M. Schaddelee MP, et al. Eur J Pharmacol. 2005 May 9;514(2-3):131-40. doi: 10.1016/j.ejphar.2005.03.026. Eur J Pharmacol. 2005. PMID: 15910799

6

Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives.

Schaddelee MP, Voorwinden HL, van Tilburg EW, Pateman TJ, Ijzerman AP, Danhof M, de Boer AG. Schaddelee MP, et al. Eur J Pharm Sci. 2003 May;19(1):13-22. doi: 10.1016/s0928-0987(03)00034-4. Eur J Pharm Sci. 2003. PMID: 12729857

7

The effect of mirabegron, a potent and selective β3-adrenoceptor agonist, on the pharmacokinetics of CYP2D6 substrates desipramine and metoprolol.

Krauwinkel W, Dickinson J, Schaddelee M, Meijer J, Tretter R, van de Wetering J, Strabach G, van Gelderen M. Krauwinkel W, et al. Eur J Drug Metab Pharmacokinet. 2014 Mar;39(1):43-52. doi: 10.1007/s13318-013-0133-1. Epub 2013 Jun 1. Eur J Drug Metab Pharmacokinet. 2014. PMID: 23728524 Clinical Trial.

8

A quantitative benefit-risk assessment approach to improve decision making in drug development: Application of a multicriteria decision analysis model in the development of combination therapy for overactive bladder.

de Greef-van der Sandt I, Newgreen D, Schaddelee M, Dorrepaal C, Martina R, Ridder A, van Maanen R. de Greef-van der Sandt I, et al. Clin Pharmacol Ther. 2016 Apr;99(4):442-51. doi: 10.1002/cpt.271. Epub 2015 Nov 13. Clin Pharmacol Ther. 2016. PMID: 26422298 Clinical Trial.

9

Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects.

Groenendaal-van de Meent D, den Adel M, van Dijk J, Barroso-Fernandez B, El Galta R, Golor G, Schaddelee M. Groenendaal-van de Meent D, et al. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):685-692. doi: 10.1007/s13318-018-0480-z. Eur J Drug Metab Pharmacokinet. 2018. PMID: 29752643 Free PMC article. Clinical Trial.

10

Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open-Label, 1-Sequence, Crossover Studies.

Groenendaal-van de Meent D, den Adel M, Kerbusch V, van Dijk J, Shibata T, Kato K, Schaddelee M. Groenendaal-van de Meent D, et al. Clin Pharmacol Drug Dev. 2022 Apr;11(4):486-501. doi: 10.1002/cpdd.1076. Epub 2022 Feb 19. Clin Pharmacol Drug Dev. 2022. PMID: 35182045 Free PMC article. Clinical Trial.

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