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Page 1
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.
Gale NW, Dominguez MG, Noguera I, Pan L, Hughes V, Valenzuela DM, Murphy AJ, Adams NC, Lin HC, Holash J, Thurston G, Yancopoulos GD. Gale NW, et al. Among authors: valenzuela dm. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54. doi: 10.1073/pnas.0407290101. Epub 2004 Nov 1. Proc Natl Acad Sci U S A. 2004. PMID: 15520367 Free PMC article.
Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.
Li Z, Huang H, Boland P, Dominguez MG, Burfeind P, Lai KM, Lin HC, Gale NW, Daly C, Auerbach W, Valenzuela D, Yancopoulos GD, Thurston G. Li Z, et al. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22399-404. doi: 10.1073/pnas.0911189106. Epub 2009 Dec 15. Proc Natl Acad Sci U S A. 2009. PMID: 20018779 Free PMC article.
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis.
Dominguez MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, Noguera-Troise I, Murphy AJ, Valenzuela DM, Davis S, Thurston G, Yancopoulos GD, Gale NW. Dominguez MG, et al. Among authors: valenzuela dm. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8. doi: 10.1073/pnas.0611510104. Epub 2007 Feb 21. Proc Natl Acad Sci U S A. 2007. PMID: 17360632 Free PMC article.
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.
Anderson KD, Pan L, Yang XM, Hughes VC, Walls JR, Dominguez MG, Simmons MV, Burfeind P, Xue Y, Wei Y, Macdonald LE, Thurston G, Daly C, Lin HC, Economides AN, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW. Anderson KD, et al. Among authors: valenzuela dm. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2807-12. doi: 10.1073/pnas.1019761108. Epub 2011 Jan 31. Proc Natl Acad Sci U S A. 2011. PMID: 21282641 Free PMC article.
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD. Valenzuela DM, et al. Nat Biotechnol. 2003 Jun;21(6):652-9. doi: 10.1038/nbt822. Epub 2003 May 5. Nat Biotechnol. 2003. PMID: 12730667
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ. Macdonald LE, et al. Among authors: valenzuela dm. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501. doi: 10.1073/pnas.0409849102. Epub 2005 Feb 7. Proc Natl Acad Sci U S A. 2005. PMID: 15699348 Free PMC article.
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Hooper AT, Shmelkov SV, Gupta S, Milde T, Bambino K, Gillen K, Goetz M, Chavala S, Baljevic M, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Vahdat L, Evans T, Rafii S. Hooper AT, et al. Among authors: valenzuela dm. Circ Res. 2009 Jul 17;105(2):201-8. doi: 10.1161/CIRCRESAHA.109.196790. Epub 2009 Jun 18. Circ Res. 2009. PMID: 19542015 Free PMC article.
Conditionals by inversion provide a universal method for the generation of conditional alleles.
Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD. Economides AN, et al. Among authors: valenzuela dm. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88. doi: 10.1073/pnas.1217812110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918385 Free PMC article.
128 results