Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.
Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, Onda H, Tatemoto K, Fujino M.
Habata Y, et al. Among authors: hinuma s.
Biochim Biophys Acta. 1999 Oct 13;1452(1):25-35. doi: 10.1016/s0167-4889(99)00114-7.
Biochim Biophys Acta. 1999.
PMID: 10525157
Free article.
By using a strategy that we have developed to search for the ligands of orphan seven-transmembrane-domain receptors [S. Hinuma et al., Nature 393 (1998) 272-276], we have recently identified a natural ligand, apelin, for the orphan 7TMR, APJ [K. ...
By using a strategy that we have developed to search for the ligands of orphan seven-transmembrane-domain receptors [S. Hinuma …