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Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway.
Sancho R, Márquez N, Gómez-Gonzalo M, Calzado MA, Bettoni G, Coiras MT, Alcamí J, López-Cabrera M, Appendino G, Muñoz E. Sancho R, et al. Among authors: appendino g. J Biol Chem. 2004 Sep 3;279(36):37349-59. doi: 10.1074/jbc.M401993200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218031 Free article.
Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca(2+) from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-kappaB, and activator protein 1 in T lymphocytes.
Navarrete C, Sancho R, Caballero FJ, Pollastro F, Fiebich BL, Sterner O, Appendino G, Muñoz E. Navarrete C, et al. Among authors: appendino g. J Pharmacol Exp Ther. 2006 Oct;319(1):422-30. doi: 10.1124/jpet.106.108209. Epub 2006 Jul 13. J Pharmacol Exp Ther. 2006. PMID: 16840645
274 results