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The SH3 domain of Eps8 exists as a novel intertwined dimer.
Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME. Kishan KV, et al. Among authors: di fiore pp. Nat Struct Biol. 1997 Sep;4(9):739-43. doi: 10.1038/nsb0997-739. Nat Struct Biol. 1997. PMID: 9303002
EPS8 and E3B1 transduce signals from Ras to Rac.
Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP. Scita G, et al. Among authors: di fiore pp. Nature. 1999 Sep 16;401(6750):290-3. doi: 10.1038/45822. Nature. 1999. PMID: 10499589
Signaling from Ras to Rac and beyond: not just a matter of GEFs.
Scita G, Tenca P, Frittoli E, Tocchetti A, Innocenti M, Giardina G, Di Fiore PP. Scita G, et al. Among authors: di fiore pp. EMBO J. 2000 Jun 1;19(11):2393-8. doi: 10.1093/emboj/19.11.2393. EMBO J. 2000. PMID: 10835338 Free PMC article. Review.
Numb is an endocytic protein.
Santolini E, Puri C, Salcini AE, Gagliani MC, Pelicci PG, Tacchetti C, Di Fiore PP. Santolini E, et al. Among authors: di fiore pp. J Cell Biol. 2000 Dec 11;151(6):1345-52. doi: 10.1083/jcb.151.6.1345. J Cell Biol. 2000. PMID: 11121447 Free PMC article.
An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.
Scita G, Tenca P, Areces LB, Tocchetti A, Frittoli E, Giardina G, Ponzanelli I, Sini P, Innocenti M, Di Fiore PP. Scita G, et al. Among authors: di fiore pp. J Cell Biol. 2001 Sep 3;154(5):1031-44. doi: 10.1083/jcb.200103146. Epub 2001 Aug 27. J Cell Biol. 2001. PMID: 11524436 Free PMC article.
293 results