Pineda AO - Search Results

1

Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form.

Pineda AO, Zhang E, Guinto ER, Savvides SN, Tulinsky A, Di Cera E. Pineda AO, et al. Biophys Chem. 2004 Dec 20;112(2-3):253-6. doi: 10.1016/j.bpc.2004.07.027. Biophys Chem. 2004. PMID: 15572256

2

The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I.

Pineda AO, Cantwell AM, Bush LA, Rose T, Di Cera E. Pineda AO, et al. J Biol Chem. 2002 Aug 30;277(35):32015-9. doi: 10.1074/jbc.M205009200. Epub 2002 Jun 14. J Biol Chem. 2002. PMID: 12068020 Free article.

3

Crystal structure of the anticoagulant slow form of thrombin.

Pineda AO, Savvides SN, Waksman G, Di Cera E. Pineda AO, et al. J Biol Chem. 2002 Oct 25;277(43):40177-80. doi: 10.1074/jbc.C200465200. Epub 2002 Aug 29. J Biol Chem. 2002. PMID: 12205081 Free article.

4

Molecular dissection of Na+ binding to thrombin.

Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Pineda AO, et al. J Biol Chem. 2004 Jul 23;279(30):31842-53. doi: 10.1074/jbc.M401756200. Epub 2004 May 19. J Biol Chem. 2004. PMID: 15152000 Free article.

5

The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket.

Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. Pineda AO, et al. J Biol Chem. 2004 Sep 17;279(38):39824-8. doi: 10.1074/jbc.M407272200. Epub 2004 Jul 13. J Biol Chem. 2004. PMID: 15252033 Free article.

6

Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.

Xu H, Bush LA, Pineda AO, Caccia S, Di Cera E. Xu H, et al. Among authors: pineda ao. J Biol Chem. 2005 Mar 4;280(9):7956-61. doi: 10.1074/jbc.M412869200. Epub 2004 Dec 6. J Biol Chem. 2005. PMID: 15582990 Free article.

7

Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases.

Bobofchak KM, Pineda AO, Mathews FS, Di Cera E. Bobofchak KM, et al. Among authors: pineda ao. J Biol Chem. 2005 Jul 8;280(27):25644-50. doi: 10.1074/jbc.M503499200. Epub 2005 May 12. J Biol Chem. 2005. PMID: 15890651 Free article.

8

Crystal structure of thrombin in a self-inhibited conformation.

Pineda AO, Chen ZW, Bah A, Garvey LC, Mathews FS, Di Cera E. Pineda AO, et al. J Biol Chem. 2006 Oct 27;281(43):32922-8. doi: 10.1074/jbc.M605530200. Epub 2006 Sep 5. J Biol Chem. 2006. PMID: 16954215 Free article.

9

Crystal structure of thrombin in complex with fibrinogen gamma' peptide.

Pineda AO, Chen ZW, Marino F, Mathews FS, Mosesson MW, Di Cera E. Pineda AO, et al. Biophys Chem. 2007 Feb;125(2-3):556-9. doi: 10.1016/j.bpc.2006.08.005. Epub 2006 Aug 23. Biophys Chem. 2007. PMID: 16962697

10

Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery.

Bush-Pelc LA, Marino F, Chen Z, Pineda AO, Mathews FS, Di Cera E. Bush-Pelc LA, et al. Among authors: pineda ao. J Biol Chem. 2007 Sep 14;282(37):27165-27170. doi: 10.1074/jbc.M703202200. Epub 2007 Jul 18. J Biol Chem. 2007. PMID: 17636263 Free article.

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