Hayes JD - Search Results

1

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M. Katoh Y, et al. Among authors: hayes jd. Arch Biochem Biophys. 2005 Jan 15;433(2):342-50. doi: 10.1016/j.abb.2004.10.012. Arch Biochem Biophys. 2005. PMID: 15581590 Review.

2

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.

McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. Among authors: hayes jd. J Biol Chem. 2004 Jul 23;279(30):31556-67. doi: 10.1074/jbc.M403061200. Epub 2004 May 13. J Biol Chem. 2004. PMID: 15143058 Free article.

3

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. Among authors: hayes jd. J Biol Chem. 2006 Aug 25;281(34):24756-68. doi: 10.1074/jbc.M601119200. Epub 2006 Jun 21. J Biol Chem. 2006. PMID: 16790436 Free article.

4

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.

Zhang Y, Crouch DH, Yamamoto M, Hayes JD. Zhang Y, et al. Among authors: hayes jd. Biochem J. 2006 Nov 1;399(3):373-85. doi: 10.1042/BJ20060725. Biochem J. 2006. PMID: 16872277 Free PMC article.

5

Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.

Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M. Ohtsuji M, et al. Among authors: hayes jd. J Biol Chem. 2008 Nov 28;283(48):33554-62. doi: 10.1074/jbc.M804597200. Epub 2008 Sep 30. J Biol Chem. 2008. PMID: 18826952 Free PMC article.

6

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.

Hayes JD, McMahon M. Hayes JD, et al. Trends Biochem Sci. 2009 Apr;34(4):176-88. doi: 10.1016/j.tibs.2008.12.008. Epub 2009 Mar 25. Trends Biochem Sci. 2009. PMID: 19321346 Review.

7

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.

McMahon M, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. Among authors: hayes jd. J Biol Chem. 2003 Jun 13;278(24):21592-600. doi: 10.1074/jbc.M300931200. Epub 2003 Apr 7. J Biol Chem. 2003. PMID: 12682069 Free article.

8

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.

Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD. Nioi P, et al. Among authors: hayes jd. Biochem J. 2003 Sep 1;374(Pt 2):337-48. doi: 10.1042/BJ20030754. Biochem J. 2003. PMID: 12816537 Free PMC article.

9

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

Hayes JD, McMahon M. Hayes JD, et al. Mol Cell. 2006 Mar 17;21(6):732-4. doi: 10.1016/j.molcel.2006.03.004. Mol Cell. 2006. PMID: 16543142 Free article.

10

The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.

Zhang Y, Kobayashi A, Yamamoto M, Hayes JD. Zhang Y, et al. Among authors: hayes jd. J Biol Chem. 2009 Jan 30;284(5):3195-3210. doi: 10.1074/jbc.M805337200. Epub 2008 Dec 1. J Biol Chem. 2009. PMID: 19047052 Free article.

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