Brown KD - Search Results

1

The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways.

Kim WJ, Beardsley DI, Adamson AW, Brown KD. Kim WJ, et al. Among authors: brown kd. Toxicol Appl Pharmacol. 2005 Jan 1;202(1):84-98. doi: 10.1016/j.taap.2004.06.009. Toxicol Appl Pharmacol. 2005. PMID: 15589979

2

ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation.

Adamson AW, Kim WJ, Shangary S, Baskaran R, Brown KD. Adamson AW, et al. Among authors: brown kd. J Biol Chem. 2002 Oct 11;277(41):38222-9. doi: 10.1074/jbc.M204409200. Epub 2002 Jul 31. J Biol Chem. 2002. PMID: 12151394 Free article.

3

Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2.

Adamson AW, Beardsley DI, Kim WJ, Gao Y, Baskaran R, Brown KD. Adamson AW, et al. Among authors: brown kd. Mol Biol Cell. 2005 Mar;16(3):1513-26. doi: 10.1091/mbc.e04-02-0089. Epub 2005 Jan 12. Mol Biol Cell. 2005. PMID: 15647386 Free PMC article.

4

N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner.

Beardsley DI, Kim WJ, Brown KD. Beardsley DI, et al. Among authors: brown kd. Mol Pharmacol. 2005 Oct;68(4):1049-60. doi: 10.1124/mol.105.013888. Epub 2005 Jun 30. Mol Pharmacol. 2005. PMID: 15994368

5

N-methyl-N'-nitro-N-nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts.

Lee MW, Kim WJ, Beardsley DI, Brown KD. Lee MW, et al. Among authors: brown kd. DNA Cell Biol. 2007 Sep;26(9):683-94. doi: 10.1089/dna.2007.0594. DNA Cell Biol. 2007. PMID: 17678437

6

MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine.

Kim WJ, Rajasekaran B, Brown KD. Kim WJ, et al. Among authors: brown kd. J Biol Chem. 2007 Nov 2;282(44):32021-31. doi: 10.1074/jbc.M701451200. Epub 2007 Sep 5. J Biol Chem. 2007. PMID: 17804421 Free article.

7

Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line.

Kim WJ, Vo QN, Shrivastav M, Lataxes TA, Brown KD. Kim WJ, et al. Among authors: brown kd. Oncogene. 2002 May 30;21(24):3864-71. doi: 10.1038/sj.onc.1205485. Oncogene. 2002. PMID: 12032824

8

The mismatch repair system is required for S-phase checkpoint activation.

Brown KD, Rathi A, Kamath R, Beardsley DI, Zhan Q, Mannino JL, Baskaran R. Brown KD, et al. Nat Genet. 2003 Jan;33(1):80-4. doi: 10.1038/ng1052. Epub 2002 Nov 25. Nat Genet. 2003. PMID: 12447371

9

Characterization of the novel amplified in breast cancer-1 (NABC1) gene product.

Beardsley DI, Kowbel D, Lataxes TA, Mannino JM, Xin H, Kim WJ, Collins C, Brown KD. Beardsley DI, et al. Among authors: brown kd. Exp Cell Res. 2003 Nov 1;290(2):402-13. doi: 10.1016/s0014-4827(03)00353-7. Exp Cell Res. 2003. PMID: 14567997

10

The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint.

Wakeman TP, Kim WJ, Callens S, Chiu A, Brown KD, Xu B. Wakeman TP, et al. Among authors: brown kd. Mutat Res. 2004 Oct 4;554(1-2):241-51. doi: 10.1016/j.mrfmmm.2004.05.006. Mutat Res. 2004. PMID: 15450422

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