Varney MA - Search Results

1

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice.

Bradbury MJ, Campbell U, Giracello D, Chapman D, King C, Tehrani L, Cosford ND, Anderson J, Varney MA, Strack AM. Bradbury MJ, et al. Among authors: varney ma. J Pharmacol Exp Ther. 2005 Apr;313(1):395-402. doi: 10.1124/jpet.104.076406. Epub 2004 Dec 8. J Pharmacol Exp Ther. 2005. PMID: 15590770

2

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).

Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C, Cosford ND, Varney MA. Anderson JJ, et al. Among authors: varney ma. Eur J Pharmacol. 2003 Jul 18;473(1):35-40. doi: 10.1016/s0014-2999(03)01935-6. Eur J Pharmacol. 2003. PMID: 12877935

3

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.

Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA. Anderson JJ, et al. Among authors: varney ma. J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51. doi: 10.1124/jpet.102.040618. J Pharmacol Exp Ther. 2002. PMID: 12438526

4

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. Cosford ND, et al. Among authors: varney ma. J Med Chem. 2003 Jan 16;46(2):204-6. doi: 10.1021/jm025570j. J Med Chem. 2003. PMID: 12519057

5

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.

Cosford ND, Roppe J, Tehrani L, Schweiger EJ, Seiders TJ, Chaudary A, Rao S, Varney MA. Cosford ND, et al. Among authors: varney ma. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. doi: 10.1016/s0960-894x(02)00997-6. Bioorg Med Chem Lett. 2003. PMID: 12565928

6

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.

Busse CS, Brodkin J, Tattersall D, Anderson JJ, Warren N, Tehrani L, Bristow LJ, Varney MA, Cosford ND. Busse CS, et al. Among authors: varney ma. Neuropsychopharmacology. 2004 Nov;29(11):1971-9. doi: 10.1038/sj.npp.1300540. Neuropsychopharmacology. 2004. PMID: 15305166

7

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.

Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. Varney MA, et al. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81. J Pharmacol Exp Ther. 1999. PMID: 10381773

8

Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems.

Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Schaffhauser H, Rao SP, Varney MA, Anderson JJ. Bradbury MJ, et al. Among authors: varney ma. Neuropharmacology. 2003 Apr;44(5):562-72. doi: 10.1016/s0028-3908(03)00048-0. Neuropharmacology. 2003. PMID: 12668042

9

Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat.

Urban MO, Hama AT, Bradbury M, Anderson J, Varney MA, Bristow L. Urban MO, et al. Among authors: varney ma. Neuropharmacology. 2003 Jun;44(8):983-93. doi: 10.1016/s0028-3908(03)00118-7. Neuropharmacology. 2003. PMID: 12763091

10

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND. Roppe J, et al. Among authors: varney ma. J Med Chem. 2004 Sep 9;47(19):4645-8. doi: 10.1021/jm049828c. J Med Chem. 2004. PMID: 15341479

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