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806 results

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Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y. Shibata H, et al. Among authors: mukai y. Clin Cancer Res. 2004 Dec 15;10(24):8293-300. doi: 10.1158/1078-0432.CCR-04-0770. Clin Cancer Res. 2004. PMID: 15623605
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
Yamamoto Y, Tsutsumi Y, Yoshioka Y, Nishibata T, Kobayashi K, Okamoto T, Mukai Y, Shimizu T, Nakagawa S, Nagata S, Mayumi T. Yamamoto Y, et al. Among authors: mukai y. Nat Biotechnol. 2003 May;21(5):546-52. doi: 10.1038/nbt812. Epub 2003 Mar 31. Nat Biotechnol. 2003. PMID: 12665803
Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency.
Yoshioka Y, Tsutsumi Y, Ikemizu S, Yamamoto Y, Shibata H, Nishibata T, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Nagata S, Yamagata Y, Mayumi T. Yoshioka Y, et al. Among authors: mukai y. Biochem Biophys Res Commun. 2004 Mar 19;315(4):808-14. doi: 10.1016/j.bbrc.2004.01.125. Biochem Biophys Res Commun. 2004. PMID: 14985084
Phage display and PEGylation of therapeutic proteins.
Mukai Y, Yoshioka Y, Tsutsumi Y. Mukai Y, et al. Comb Chem High Throughput Screen. 2005 Mar;8(2):145-52. doi: 10.2174/1386207053258578. Comb Chem High Throughput Screen. 2005. PMID: 15777178 Review.
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y. Shibata H, et al. Among authors: mukai y. J Biol Chem. 2008 Jan 11;283(2):998-1007. doi: 10.1074/jbc.M707933200. Epub 2007 Nov 14. J Biol Chem. 2008. PMID: 18003610 Free article.
806 results