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Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y. Shibata H, et al. Among authors: nagata s. Clin Cancer Res. 2004 Dec 15;10(24):8293-300. doi: 10.1158/1078-0432.CCR-04-0770. Clin Cancer Res. 2004. PMID: 15623605
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
Yamamoto Y, Tsutsumi Y, Yoshioka Y, Nishibata T, Kobayashi K, Okamoto T, Mukai Y, Shimizu T, Nakagawa S, Nagata S, Mayumi T. Yamamoto Y, et al. Among authors: nagata s. Nat Biotechnol. 2003 May;21(5):546-52. doi: 10.1038/nbt812. Epub 2003 Mar 31. Nat Biotechnol. 2003. PMID: 12665803
Optimal site-specific PEGylation of mutant TNF-alpha improves its antitumor potency.
Yoshioka Y, Tsutsumi Y, Ikemizu S, Yamamoto Y, Shibata H, Nishibata T, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Nagata S, Yamagata Y, Mayumi T. Yoshioka Y, et al. Among authors: nagata s. Biochem Biophys Res Commun. 2004 Mar 19;315(4):808-14. doi: 10.1016/j.bbrc.2004.01.125. Biochem Biophys Res Commun. 2004. PMID: 14985084
COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions.
Urano E, Okamura T, Ono C, Ueno S, Nagata S, Kamada H, Higuchi M, Furukawa M, Kamitani W, Matsuura Y, Kawaoka Y, Yasutomi Y. Urano E, et al. Among authors: nagata s. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104847118. doi: 10.1073/pnas.2104847118. Proc Natl Acad Sci U S A. 2021. PMID: 34625475 Free PMC article.
2,147 results