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Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window.
Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y. Shibata H, et al. Among authors: okamoto t. Clin Cancer Res. 2004 Dec 15;10(24):8293-300. doi: 10.1158/1078-0432.CCR-04-0770. Clin Cancer Res. 2004. PMID: 15623605
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity.
Yamamoto Y, Tsutsumi Y, Yoshioka Y, Nishibata T, Kobayashi K, Okamoto T, Mukai Y, Shimizu T, Nakagawa S, Nagata S, Mayumi T. Yamamoto Y, et al. Among authors: okamoto t. Nat Biotechnol. 2003 May;21(5):546-52. doi: 10.1038/nbt812. Epub 2003 Mar 31. Nat Biotechnol. 2003. PMID: 12665803
A novel cytomedical vehicle capable of protecting cells against complement.
Yoshioka Y, Suzuki R, Oka H, Okada N, Okamoto T, Yoshioka T, Mukai Y, Shibata H, Tsutsumi Y, Nakagawa S, Miyazaki J, Mayumi T. Yoshioka Y, et al. Among authors: okamoto t. Biochem Biophys Res Commun. 2003 May 30;305(2):353-8. doi: 10.1016/s0006-291x(03)00761-7. Biochem Biophys Res Commun. 2003. PMID: 12745082
Incorporation of adult organ-derived endothelial cells into tumor blood vessel.
Koizumi K, Tsutsumi Y, Kamada H, Yoshioka Y, Watanabe M, Yamamoto Y, Okamoto T, Mukai Y, Nakagawa S, Tani Y, Mayumi T. Koizumi K, et al. Among authors: okamoto t. Biochem Biophys Res Commun. 2003 Jun 20;306(1):219-24. doi: 10.1016/s0006-291x(03)00938-0. Biochem Biophys Res Commun. 2003. PMID: 12788091
Anti-angiogenic effects of dimethyl sulfoxide on endothelial cells.
Koizumi K, Tsutsumi Y, Yoshioka Y, Watanabe M, Okamoto T, Mukai Y, Nakagawa S, Mayumi T. Koizumi K, et al. Among authors: okamoto t. Biol Pharm Bull. 2003 Sep;26(9):1295-8. doi: 10.1248/bpb.26.1295. Biol Pharm Bull. 2003. PMID: 12951474 Free article.
The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.
Kaneda Y, Tsutsumi Y, Yoshioka Y, Kamada H, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. Kaneda Y, et al. Among authors: okamoto t. Biomaterials. 2004 Jul;25(16):3259-66. doi: 10.1016/j.biomaterials.2003.10.003. Biomaterials. 2004. PMID: 14980420
4,173 results