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Spironolactone modulates expressions of cardiac mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase 2 and prevents ventricular remodeling in post-infarct rat hearts.
Takeda M, Tatsumi T, Matsunaga S, Hayashi H, Kimata M, Honsho S, Nishikawa S, Mano A, Shiraishi J, Yamada H, Takahashi T, Matoba S, Kobara M, Matsubara H. Takeda M, et al. Among authors: nishikawa s. Hypertens Res. 2007 May;30(5):427-37. doi: 10.1291/hypres.30.427. Hypertens Res. 2007. PMID: 17587755
Aldosterone directly induces myocyte apoptosis through calcineurin-dependent pathways.
Mano A, Tatsumi T, Shiraishi J, Keira N, Nomura T, Takeda M, Nishikawa S, Yamanaka S, Matoba S, Kobara M, Tanaka H, Shirayama T, Takamatsu T, Nozawa Y, Matsubara H. Mano A, et al. Among authors: nishikawa s. Circulation. 2004 Jul 20;110(3):317-23. doi: 10.1161/01.CIR.0000135599.33787.CA. Epub 2004 Jul 12. Circulation. 2004. Retraction in: Circulation. 2013 Jun 11;127(23):e842. doi: 10.1161/CIR.0b013e31829bd2f4 PMID: 15249508 Retracted.
1,298 results