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Page 1
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Eastman RT, et al. Among authors: yokoyama k. J Biol Chem. 2005 Apr 8;280(14):13554-9. doi: 10.1074/jbc.M413556200. Epub 2005 Jan 20. J Biol Chem. 2005. PMID: 15661734 Free article.
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Nallan L, Bauer KD, Bendale P, Rivas K, Yokoyama K, Hornéy CP, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Hamilton A, Sebti S, Windsor WT, Weber PC, Buckner FS, Chakrabarti D, Gelb MH, Van Voorhis WC. Nallan L, et al. Among authors: yokoyama k. J Med Chem. 2005 Jun 2;48(11):3704-13. doi: 10.1021/jm0491039. J Med Chem. 2005. PMID: 15916422
C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins.
Gillespie JR, Yokoyama K, Lu K, Eastman RT, Bollinger JG, Van Voorhis WC, Gelb MH, Buckner FS. Gillespie JR, et al. Among authors: yokoyama k. Mol Biochem Parasitol. 2007 Jun;153(2):115-24. doi: 10.1016/j.molbiopara.2007.02.009. Epub 2007 Mar 1. Mol Biochem Parasitol. 2007. PMID: 17397944
Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase.
Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Hornéy C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH. Van Voorhis WC, et al. Among authors: yokoyama k. Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. doi: 10.1128/AAC.00246-07. Epub 2007 Jul 2. Antimicrob Agents Chemother. 2007. PMID: 17606674 Free PMC article.
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.
Bendale P, Olepu S, Suryadevara PK, Bulbule V, Rivas K, Nallan L, Smart B, Yokoyama K, Ankala S, Pendyala PR, Floyd D, Lombardo LJ, Williams DK, Buckner FS, Chakrabarti D, Verlinde CL, Van Voorhis WC, Gelb MH. Bendale P, et al. Among authors: yokoyama k. J Med Chem. 2007 Sep 20;50(19):4585-605. doi: 10.1021/jm0703340. Epub 2007 Aug 28. J Med Chem. 2007. PMID: 17722901 Free PMC article.
Protein geranylgeranyltransferase-I of Trypanosoma cruzi.
Yokoyama K, Gillespie JR, Van Voorhis WC, Buckner FS, Gelb MH. Yokoyama K, et al. Mol Biochem Parasitol. 2008 Jan;157(1):32-43. doi: 10.1016/j.molbiopara.2007.09.006. Epub 2007 Oct 2. Mol Biochem Parasitol. 2008. PMID: 17996962 Free PMC article.
3,412 results