Totzke F - Search Results

1

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.

Voigt B, Meijer L, Lozach O, Schächtele C, Totzke F, Hilgeroth A. Voigt B, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2005 Feb 1;15(3):823-5. doi: 10.1016/j.bmcl.2004.10.091. Bioorg Med Chem Lett. 2005. PMID: 15664865

2

Probing novel 1-aza-9-oxafluorenes as selective GSK-3beta inhibitors.

Voigt B, Krug M, Schächtele C, Totzke F, Hilgeroth A. Voigt B, et al. Among authors: totzke f. ChemMedChem. 2008 Jan;3(1):120-6. doi: 10.1002/cmdc.200700175. ChemMedChem. 2008. PMID: 18000938

3

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.

Krug M, Erlenkamp G, Sippl W, Schächtele C, Totzke F, Hilgeroth A. Krug M, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. doi: 10.1016/j.bmcl.2010.10.004. Epub 2010 Oct 27. Bioorg Med Chem Lett. 2010. PMID: 21035334

4

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Tell V, Holzer M, Herrmann L, Mahmoud KA, Schächtele C, Totzke F, Hilgeroth A. Tell V, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. doi: 10.1016/j.bmcl.2012.09.006. Epub 2012 Sep 13. Bioorg Med Chem Lett. 2012. PMID: 23039927

5

Approaches to a multitargeting drug development: first profiled 3- ethoxycarbonyl-1-aza-9-oxafluorenes representing a perspective compound class targeting Alzheimer disease relevant kinases CDK1, CDK5 and GSK-3β.

Hilgeroth A, Tell V, Kramer S, Totzke F, Schachtele C. Hilgeroth A, et al. Among authors: totzke f. Med Chem. 2014;10(1):90-7. doi: 10.2174/157340641001131226141606. Med Chem. 2014. PMID: 23477782

6

Discovery of 4-anilino α-carbolines as novel Brk inhibitors.

Mahmoud KA, Krug M, Wersig T, Slynko I, Schächtele C, Totzke F, Sippl W, Hilgeroth A. Mahmoud KA, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51. doi: 10.1016/j.bmcl.2014.03.002. Epub 2014 Mar 12. Bioorg Med Chem Lett. 2014. PMID: 24650640

7

Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors.

Fischer T, Krüger T, Najjar A, Totzke F, Schächtele C, Sippl W, Ritter C, Hilgeroth A. Fischer T, et al. Among authors: totzke f. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. doi: 10.1016/j.bmcl.2017.04.053. Epub 2017 Apr 19. Bioorg Med Chem Lett. 2017. PMID: 28478927

8

Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.

Peifer C, Stoiber T, Unger E, Totzke F, Schächtele C, Marmé D, Brenk R, Klebe G, Schollmeyer D, Dannhardt G. Peifer C, et al. Among authors: totzke f. J Med Chem. 2006 Feb 23;49(4):1271-81. doi: 10.1021/jm0580297. J Med Chem. 2006. PMID: 16480264

9

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.

Beckers T, Sellmer A, Eichhorn E, Pongratz H, Schächtele C, Totzke F, Kelter G, Krumbach R, Fiebig HH, Böhmer FD, Mahboobi S. Beckers T, et al. Among authors: totzke f. Bioorg Med Chem. 2012 Jan 1;20(1):125-36. doi: 10.1016/j.bmc.2011.11.023. Epub 2011 Nov 20. Bioorg Med Chem. 2012. PMID: 22169601

10

Assessing the target differentiation potential of imidazole-based protein kinase inhibitors.

Dimova D, Iyer P, Vogt M, Totzke F, Kubbutat MH, Schächtele C, Laufer S, Bajorath J. Dimova D, et al. Among authors: totzke f. J Med Chem. 2012 Dec 27;55(24):11067-71. doi: 10.1021/jm3014508. Epub 2012 Dec 11. J Med Chem. 2012. PMID: 23210446

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