Chen CS - Search Results

1

Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance.

Tseng PH, Lin HP, Zhu J, Chen KF, Hade EM, Young DC, Byrd JC, Grever M, Johnson K, Druker BJ, Chen CS. Tseng PH, et al. Among authors: chen cs, chen kf. Blood. 2005 May 15;105(10):4021-7. doi: 10.1182/blood-2004-07-2967. Epub 2005 Jan 21. Blood. 2005. PMID: 15665113 Free PMC article.

2

Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents.

Zhu J, Song X, Lin HP, Young DC, Yan S, Marquez VE, Chen CS. Zhu J, et al. Among authors: chen cs. J Natl Cancer Inst. 2002 Dec 4;94(23):1745-57. doi: 10.1093/jnci/94.23.1745. J Natl Cancer Inst. 2002. PMID: 12464646

3

3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.

Kulp SK, Yang YT, Hung CC, Chen KF, Lai JP, Tseng PH, Fowble JW, Ward PJ, Chen CS. Kulp SK, et al. Among authors: chen cs, chen kf. Cancer Res. 2004 Feb 15;64(4):1444-51. doi: 10.1158/0008-5472.can-03-2396. Cancer Res. 2004. PMID: 14973075

4

From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.

Zhu J, Huang JW, Tseng PH, Yang YT, Fowble J, Shiau CW, Shaw YJ, Kulp SK, Chen CS. Zhu J, et al. Among authors: chen cs. Cancer Res. 2004 Jun 15;64(12):4309-18. doi: 10.1158/0008-5472.CAN-03-4063. Cancer Res. 2004. PMID: 15205346

5

A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism.

Johnson AJ, Smith LL, Zhu J, Heerema NA, Jefferson S, Mone A, Grever M, Chen CS, Byrd JC. Johnson AJ, et al. Among authors: chen cs. Blood. 2005 Mar 15;105(6):2504-9. doi: 10.1182/blood-2004-05-1957. Epub 2004 Sep 28. Blood. 2005. PMID: 15454489 Free article.

6

Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor.

Tseng PH, Wang YC, Weng SC, Weng JR, Chen CS, Brueggemeier RW, Shapiro CL, Chen CY, Dunn SE, Pollak M, Chen CS. Tseng PH, et al. Among authors: chen cs, chen cy. Mol Pharmacol. 2006 Nov;70(5):1534-41. doi: 10.1124/mol.106.023911. Epub 2006 Aug 3. Mol Pharmacol. 2006. PMID: 16887935

7

OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells.

Liu TM, Ling Y, Woyach JA, Beckwith K, Yeh YY, Hertlein E, Zhang X, Lehman A, Awan F, Jones JA, Andritsos LA, Maddocks K, MacMurray J, Salunke SB, Chen CS, Phelps MA, Byrd JC, Johnson AJ. Liu TM, et al. Among authors: chen cs. Blood. 2015 Jan 8;125(2):284-95. doi: 10.1182/blood-2014-06-583518. Epub 2014 Oct 7. Blood. 2015. PMID: 25293770 Free PMC article.

8

Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells.

Yang CC, Lin HP, Chen CS, Yang YT, Tseng PH, Rangnekar VM, Chen CS. Yang CC, et al. Among authors: chen cs. J Biol Chem. 2003 Jul 11;278(28):25872-8. doi: 10.1074/jbc.M301744200. Epub 2003 May 8. J Biol Chem. 2003. PMID: 12738789 Free article.

9

Celecoxib derivatives induce apoptosis via the disruption of mitochondrial membrane potential and activation of caspase 9.

Ding H, Han C, Zhu J, Chen CS, D'Ambrosio SM. Ding H, et al. Among authors: chen cs. Int J Cancer. 2005 Feb 20;113(5):803-10. doi: 10.1002/ijc.20639. Int J Cancer. 2005. PMID: 15499625

10

Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms.

Lin HP, Kulp SK, Tseng PH, Yang YT, Yang CC, Chen CS, Chen CS. Lin HP, et al. Among authors: chen cs. Mol Cancer Ther. 2004 Dec;3(12):1671-80. Mol Cancer Ther. 2004. PMID: 15634661

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