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BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma.
Loukinov DI, Pugacheva E, Vatolin S, Pack SD, Moon H, Chernukhin I, Mannan P, Larsson E, Kanduri C, Vostrov AA, Cui H, Niemitz EL, Rasko JE, Docquier FM, Kistler M, Breen JJ, Zhuang Z, Quitschke WW, Renkawitz R, Klenova EM, Feinberg AP, Ohlsson R, Morse HC 3rd, Lobanenkov VV. Loukinov DI, et al. Among authors: ohlsson r. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11. doi: 10.1073/pnas.092123699. Proc Natl Acad Sci U S A. 2002. PMID: 12011441 Free PMC article.
Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
Pant V, Kurukuti S, Pugacheva E, Shamsuddin S, Mariano P, Renkawitz R, Klenova E, Lobanenkov V, Ohlsson R. Pant V, et al. Among authors: ohlsson r. Mol Cell Biol. 2004 Apr;24(8):3497-504. doi: 10.1128/MCB.24.8.3497-3504.2004. Mol Cell Biol. 2004. PMID: 15060168 Free PMC article.
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2.
Kurukuti S, Tiwari VK, Tavoosidana G, Pugacheva E, Murrell A, Zhao Z, Lobanenkov V, Reik W, Ohlsson R. Kurukuti S, et al. Among authors: ohlsson r. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10684-9. doi: 10.1073/pnas.0600326103. Epub 2006 Jun 30. Proc Natl Acad Sci U S A. 2006. PMID: 16815976 Free PMC article.
149 results