Parniak MA - Search Results

1

Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.

Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ, Parniak MA, Miller MD, Lewis D. Shaw-Reid CA, et al. Among authors: parniak ma. Biochemistry. 2005 Feb 8;44(5):1595-606. doi: 10.1021/bi0486740. Biochemistry. 2005. PMID: 15683243

2

3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase.

Dharmasena S, Pongracz Z, Arnold E, Sarafianos SG, Parniak MA. Dharmasena S, et al. Among authors: parniak ma. Biochemistry. 2007 Jan 23;46(3):828-36. doi: 10.1021/bi061364s. Biochemistry. 2007. PMID: 17223704

3

Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone.

Borkow G, Fletcher RS, Barnard J, Arion D, Motakis D, Dmitrienko GI, Parniak MA. Borkow G, et al. Among authors: parniak ma. Biochemistry. 1997 Mar 18;36(11):3179-85. doi: 10.1021/bi9624696. Biochemistry. 1997. PMID: 9115994

4

Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds.

Fletcher RS, Arion D, Borkow G, Wainberg MA, Dmitrienko GI, Parniak MA. Fletcher RS, et al. Among authors: parniak ma. Biochemistry. 1995 Aug 15;34(32):10106-12. doi: 10.1021/bi00032a002. Biochemistry. 1995. PMID: 7543775

5

Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme.

Fletcher RS, Syed K, Mithani S, Dmitrienko GI, Parniak MA. Fletcher RS, et al. Among authors: parniak ma. Biochemistry. 1995 Apr 4;34(13):4346-53. doi: 10.1021/bi00013a025. Biochemistry. 1995. PMID: 7535561

6

The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase.

Barnard J, Borkow G, Parniak MA. Barnard J, et al. Among authors: parniak ma. Biochemistry. 1997 Jun 24;36(25):7786-92. doi: 10.1021/bi970140u. Biochemistry. 1997. PMID: 9201921

7

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

Parniak MA, Min KL, Budihas SR, Le Grice SF, Beutler JA. Parniak MA, et al. Anal Biochem. 2003 Nov 1;322(1):33-9. doi: 10.1016/j.ab.2003.06.001. Anal Biochem. 2003. PMID: 14705777

8

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.

Arion D, Kaushik N, McCormick S, Borkow G, Parniak MA. Arion D, et al. Among authors: parniak ma. Biochemistry. 1998 Nov 10;37(45):15908-17. doi: 10.1021/bi981200e. Biochemistry. 1998. PMID: 9843396

9

Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors.

Sluis-Cremer N, Arion D, Parniak MA. Sluis-Cremer N, et al. Among authors: parniak ma. Mol Pharmacol. 2002 Aug;62(2):398-405. doi: 10.1124/mol.62.2.398. Mol Pharmacol. 2002. PMID: 12130693

10

Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis.

Sluis-Cremer N, Kempner E, Parniak MA. Sluis-Cremer N, et al. Among authors: parniak ma. Protein Sci. 2003 Sep;12(9):2081-6. doi: 10.1110/ps.03130503. Protein Sci. 2003. PMID: 12931006 Free PMC article.

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