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Page 1
2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Ducharme Y, Blouin M, Carrière MC, Chateauneuf A, Côté B, Denis D, Frenette R, Greig G, Kargman S, Lamontagne S, Martins E, Nantel F, O'Neill G, Sawyer N, Metters KM, Friesen RW. Ducharme Y, et al. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1155-60. doi: 10.1016/j.bmcl.2004.12.005. Bioorg Med Chem Lett. 2005. PMID: 15686932
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters.
Frenette R, Blouin M, Brideau C, Chauret N, Ducharme Y, Friesen RW, Hamel P, Jones TR, Laliberté F, Li C, Masson P, McAuliffe M, Girard Y. Frenette R, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3009-13. doi: 10.1016/s0960-894x(02)00615-7. Bioorg Med Chem Lett. 2002. PMID: 12270195
Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.
Côté B, Frenette R, Prescott S, Blouin M, Brideau C, Ducharme Y, Friesen RW, Laliberté F, Masson P, Styhler A, Girard Y. Côté B, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2003 Feb 24;13(4):741-4. doi: 10.1016/s0960-894x(02)01030-2. Bioorg Med Chem Lett. 2003. PMID: 12639571
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Friesen RW, Ducharme Y, Ball RG, Blouin M, Boulet L, Côté B, Frenette R, Girard M, Guay D, Huang Z, Jones TR, Laliberté F, Lynch JJ, Mancini J, Martins E, Masson P, Muise E, Pon DJ, Siegl PK, Styhler A, Tsou NN, Turner MJ, Young RN, Girard Y. Friesen RW, et al. Among authors: ducharme y. J Med Chem. 2003 Jun 5;46(12):2413-26. doi: 10.1021/jm0204542. J Med Chem. 2003. PMID: 12773045
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Côté B, Boulet L, Brideau C, Claveau D, Ethier D, Frenette R, Gagnon M, Giroux A, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW. Côté B, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. doi: 10.1016/j.bmcl.2007.10.033. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 18029174
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Giroux A, Boulet L, Brideau C, Chau A, Claveau D, Côté B, Ethier D, Frenette R, Gagnon M, Guay J, Guiral S, Mancini J, Martins E, Massé F, Méthot N, Riendeau D, Rubin J, Xu D, Yu H, Ducharme Y, Friesen RW. Giroux A, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. doi: 10.1016/j.bmcl.2009.08.085. Epub 2009 Aug 28. Bioorg Med Chem Lett. 2009. PMID: 19748780
The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist.
Blouin M, Han Y, Burch J, Farand J, Mellon C, Gaudreault M, Wrona M, Lévesque JF, Denis D, Mathieu MC, Stocco R, Vigneault E, Therien A, Clark P, Rowland S, Xu D, O'Neill G, Ducharme Y, Friesen R. Blouin M, et al. Among authors: ducharme y. J Med Chem. 2010 Mar 11;53(5):2227-38. doi: 10.1021/jm901771h. J Med Chem. 2010. PMID: 20163116
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z. Gallant M, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21106375
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Burch JD, Farand J, Colucci J, Sturino C, Ducharme Y, Friesen RW, Lévesque JF, Gagné S, Wrona M, Therien AG, Mathieu MC, Denis D, Vigneault E, Xu D, Clark P, Rowland S, Han Y. Burch JD, et al. Among authors: ducharme y. Bioorg Med Chem Lett. 2011 Feb 1;21(3):1041-6. doi: 10.1016/j.bmcl.2010.12.014. Epub 2010 Dec 8. Bioorg Med Chem Lett. 2011. PMID: 21215624
34 results