A PPARgamma agonist inhibits aldosterone-induced mesangial cell proliferation by blocking ROS-dependent EGFR intracellular signaling.
Yuan Y, Zhang A, Huang S, Ding G, Chen R.
Yuan Y, et al. Among authors: ding g.
Am J Physiol Renal Physiol. 2011 Feb;300(2):F393-402. doi: 10.1152/ajprenal.00418.2010. Epub 2010 Dec 1.
Am J Physiol Renal Physiol. 2011.
PMID: 21123490
Free article.
We previously showed that aldosterone (Aldo) stimulates MC proliferation via the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, which was dependent on reactive oxygen species (ROS)-mediated epithelial growth factor receptor (EGFR) transactivation (Huang S, Zhang A, Di …
We previously showed that aldosterone (Aldo) stimulates MC proliferation via the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway, whi …