Ratcliffe GS - Search Results

1

Amide bond replacements incorporated into CCK-B selective "dipeptoids".

Fincham CI, Higginbottom M, Hill DR, Horwell DC, O'Toole JC, Ratcliffe GS, Rees DC, Roberts E. Fincham CI, et al. Among authors: ratcliffe gs. J Med Chem. 1992 Apr 17;35(8):1472-84. doi: 10.1021/jm00086a017. J Med Chem. 1992. PMID: 1573640

2

Rationally designed "dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists.

Higginbottom M, Kneen C, Ratcliffe GS. Higginbottom M, et al. Among authors: ratcliffe gs. J Med Chem. 1992 May 1;35(9):1572-7. doi: 10.1021/jm00087a011. J Med Chem. 1992. PMID: 1578483

3

Quantitative structure-activity relationships (QSARs) of N-terminus fragments of NK1 tachykinin antagonists: a comparison of classical QSARs and three-dimensional QSARs from similarity matrices.

Horwell DC, Howson W, Higginbottom M, Naylor D, Ratcliffe GS, Williams S. Horwell DC, et al. Among authors: ratcliffe gs. J Med Chem. 1995 Oct 27;38(22):4454-62. doi: 10.1021/jm00022a010. J Med Chem. 1995. PMID: 7473572

4

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

Boden P, Eden JM, Hodgson J, Horwell DC, Hughes J, McKnight AT, Lewthwaite RA, Pritchard MC, Raphy J, Meecham K, Ratcliffe GS, Suman-Chauhan N, Woodruff GN. Boden P, et al. Among authors: ratcliffe gs. J Med Chem. 1996 Apr 12;39(8):1664-75. doi: 10.1021/jm950892r. J Med Chem. 1996. PMID: 8648606

5

The design of dipeptide helical mimetics: the synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes.

Horwell DC, Howson W, Ratcliffe GS, Willems HM. Horwell DC, et al. Among authors: ratcliffe gs. Bioorg Med Chem. 1996 Jan;4(1):33-42. doi: 10.1016/0968-0896(95)00169-7. Bioorg Med Chem. 1996. PMID: 8689236

6

Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.

Bryans JS, Davies N, Gee NS, Dissanayake VU, Ratcliffe GS, Horwell DC, Kneen CO, Morrell AI, Oles RJ, O'Toole JC, Perkins GM, Singh L, Suman-Chauhan N, O'Neill JA. Bryans JS, et al. Among authors: ratcliffe gs. J Med Chem. 1998 May 21;41(11):1838-45. doi: 10.1021/jm970649n. J Med Chem. 1998. PMID: 9599234

7

'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors.

Horwell D, Pritchard M, Raphy J, Ratcliffe G. Horwell D, et al. Immunopharmacology. 1996 Jun;33(1-3):68-72. doi: 10.1016/0162-3109(96)00058-6. Immunopharmacology. 1996. PMID: 8856117 Review.

8

Alanine scan and N-methyl amide derivatives of Ac-bombesin[7-14]. Development of a proposed binding conformation at the neuromedin B (NMB) and gastrin releasing peptide (GRP) receptors.

Horwell DC, Howson W, Naylor D, Osborne S, Pinnock RD, Ratcliffe GS, Suman-Chauhan N. Horwell DC, et al. Among authors: ratcliffe gs. Int J Pept Protein Res. 1996 Dec;48(6):522-31. doi: 10.1111/j.1399-3011.1996.tb00871.x. Int J Pept Protein Res. 1996. PMID: 8985785

9

An in vitro investigation into conformational aspects of gabapentin.

Bryans JS, Horwell DC, Ratcliffe GS, Receveur JM, Rubin JR. Bryans JS, et al. Among authors: ratcliffe gs. Bioorg Med Chem. 1999 May;7(5):715-21. doi: 10.1016/s0968-0896(99)00023-1. Bioorg Med Chem. 1999. PMID: 10400324

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