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Page 1
Molecular mechanism of biased signaling at the kappa opioid receptor.
El Daibani A, Paggi JM, Kim K, Laloudakis YD, Popov P, Bernhard SM, Krumm BE, Olsen RHJ, Diberto J, Carroll FI, Katritch V, Wünsch B, Dror RO, Che T. El Daibani A, et al. Among authors: dror ro. Nat Commun. 2023 Mar 11;14(1):1338. doi: 10.1038/s41467-023-37041-7. Nat Commun. 2023. PMID: 36906681 Free PMC article.
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs.
Powers AS, Pham V, Burger WAC, Thompson G, Laloudakis Y, Barnes NW, Sexton PM, Paul SM, Christopoulos A, Thal DM, Felder CC, Valant C, Dror RO. Powers AS, et al. Among authors: dror ro. Nat Chem Biol. 2023 Apr;19(4):529. doi: 10.1038/s41589-023-01297-3. Nat Chem Biol. 2023. PMID: 36879062 Free PMC article. No abstract available.
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A. Hoppe N, et al. Among authors: dror ro. Nat Struct Mol Biol. 2024 Apr;31(4):667-677. doi: 10.1038/s41594-024-01223-8. Epub 2024 Feb 7. Nat Struct Mol Biol. 2024. PMID: 38326651 Free PMC article.
Insights into distinct signaling profiles of the µOR activated by diverse agonists.
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G. Qu Q, et al. Among authors: dror ro. Nat Chem Biol. 2023 Apr;19(4):423-430. doi: 10.1038/s41589-022-01208-y. Epub 2022 Nov 21. Nat Chem Biol. 2023. PMID: 36411392 Free PMC article.
A positively tuned voltage indicator for extended electrical recordings in the brain.
Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, Fan JL, Hwang FJ, van Keulen SC, Suomivuori CM, Pang MM, Su S, Lee S, Hao YA, Zhang G, Jiang D, Pradhan L, Roth RH, Liu Y, Dorian CC, Reese AL, Negrean A, Losonczy A, Makinson CD, Wang S, Clandinin TR, Dror RO, Ding JB, Ji N, Golshani P, Giocomo LM, Bi GQ, Lin MZ. Evans SW, et al. Among authors: dror ro. Nat Methods. 2023 Jul;20(7):1104-1113. doi: 10.1038/s41592-023-01913-z. Epub 2023 Jul 6. Nat Methods. 2023. PMID: 37429962 Free PMC article.
Geometric Deep Learning for Structure-Based Ligand Design.
Powers AS, Yu HH, Suriana P, Koodli RV, Lu T, Paggi JM, Dror RO. Powers AS, et al. Among authors: dror ro. ACS Cent Sci. 2023 Nov 17;9(12):2257-2267. doi: 10.1021/acscentsci.3c00572. eCollection 2023 Dec 27. ACS Cent Sci. 2023. PMID: 38161364 Free PMC article.
122 results