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Inhibitors bound to Ca(2+)-free sarcoplasmic reticulum Ca(2+)-ATPase lock its transmembrane region but not necessarily its cytosolic region, revealing the flexibility of the loops connecting transmembrane and cytosolic domains.
Montigny C, Picard M, Lenoir G, Gauron C, Toyoshima C, Champeil P. Montigny C, et al. Among authors: champeil p. Biochemistry. 2007 Dec 25;46(51):15162-74. doi: 10.1021/bi701855r. Epub 2007 Dec 1. Biochemistry. 2007. PMID: 18052080
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