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The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J, Whisstock JC. Law RH, et al. Among authors: irving ja. J Biol Chem. 2005 Jun 10;280(23):22356-64. doi: 10.1074/jbc.M412043200. Epub 2005 Mar 10. J Biol Chem. 2005. PMID: 15760906 Free article.
Serpins in the Caenorhabditis elegans genome.
Whisstock JC, Irving JA, Bottomley SP, Pike RN, Lesk AM. Whisstock JC, et al. Among authors: irving ja. Proteins. 1999 Jul 1;36(1):31-41. doi: 10.1002/(sici)1097-0134(19990701)36:1<31::aid-prot3>3.3.co;2-h. Proteins. 1999. PMID: 10373004
Human ovalbumin serpin evolution: phylogenic analysis, gene organization, and identification of new PI8-related genes suggest that two interchromosomal and several intrachromosomal duplications generated the gene clusters at 18q21-q23 and 6p25.
Scott FL, Eyre HJ, Lioumi M, Ragoussis J, Irving JA, Sutherland GA, Bird PI. Scott FL, et al. Among authors: irving ja. Genomics. 1999 Dec 15;62(3):490-9. doi: 10.1006/geno.1999.6021. Genomics. 1999. PMID: 10644448
Protein structural alignments and functional genomics.
Irving JA, Whisstock JC, Lesk AM. Irving JA, et al. Proteins. 2001 Feb 15;42(3):378-82. doi: 10.1002/1097-0134(20010215)42:3<378::aid-prot70>3.0.co;2-3. Proteins. 2001. PMID: 11151008
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. Silverman GA, et al. Among authors: irving ja. J Biol Chem. 2001 Sep 7;276(36):33293-6. doi: 10.1074/jbc.R100016200. Epub 2001 Jul 2. J Biol Chem. 2001. PMID: 11435447 Free article. Review. No abstract available.
187 results