Miwa G - Search Results

1

Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites.

Pekol T, Daniels JS, Labutti J, Parsons I, Nix D, Baronas E, Hsieh F, Gan LS, Miwa G. Pekol T, et al. Among authors: miwa g. Drug Metab Dispos. 2005 Jun;33(6):771-7. doi: 10.1124/dmd.104.002956. Epub 2005 Mar 11. Drug Metab Dispos. 2005. PMID: 15764713

2

Evaluation of microdosing to assess pharmacokinetic linearity in rats using liquid chromatography-tandem mass spectrometry.

Balani SK, Nagaraja NV, Qian MG, Costa AO, Daniels JS, Yang H, Shimoga PR, Wu JT, Gan LS, Lee FW, Miwa GT. Balani SK, et al. Among authors: miwa gt. Drug Metab Dispos. 2006 Mar;34(3):384-8. doi: 10.1124/dmd.105.007195. Epub 2005 Dec 2. Drug Metab Dispos. 2006. PMID: 16326814

3

Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.

Lu C, Gallegos R, Li P, Xia CQ, Pusalkar S, Uttamsingh V, Nix D, Miwa GT, Gan LS. Lu C, et al. Drug Metab Dispos. 2006 Apr;34(4):702-8. doi: 10.1124/dmd.105.008060. Epub 2006 Jan 27. Drug Metab Dispos. 2006. PMID: 16443666

4

Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.

Uttamsingh V, Lu C, Miwa G, Gan LS. Uttamsingh V, et al. Among authors: miwa g. Drug Metab Dispos. 2005 Nov;33(11):1723-8. doi: 10.1124/dmd.105.005710. Epub 2005 Aug 15. Drug Metab Dispos. 2005. PMID: 16103134

5

Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: contributions from reactive oxygen species in this novel cytochrome P450 reaction.

Labutti J, Parsons I, Huang R, Miwa G, Gan LS, Daniels JS. Labutti J, et al. Among authors: miwa g. Chem Res Toxicol. 2006 Apr;19(4):539-46. doi: 10.1021/tx050313d. Chem Res Toxicol. 2006. PMID: 16608165

6

Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.

Lu C, Li P, Gallegos R, Uttamsingh V, Xia CQ, Miwa GT, Balani SK, Gan LS. Lu C, et al. Among authors: miwa gt. Drug Metab Dispos. 2006 Sep;34(9):1600-5. doi: 10.1124/dmd.106.010793. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790553

7

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

Lu C, Miwa GT, Prakash SR, Gan LS, Balani SK. Lu C, et al. Among authors: miwa gt. Drug Metab Dispos. 2007 Jan;35(1):79-85. doi: 10.1124/dmd.106.011346. Epub 2006 Oct 4. Drug Metab Dispos. 2007. PMID: 17020957

8

Interactions of cyclosporin a with breast cancer resistance protein.

Xia CQ, Liu N, Miwa GT, Gan LS. Xia CQ, et al. Among authors: miwa gt. Drug Metab Dispos. 2007 Apr;35(4):576-82. doi: 10.1124/dmd.106.011866. Epub 2007 Jan 12. Drug Metab Dispos. 2007. PMID: 17220244

9

Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells.

Xia CQ, Liu N, Yang D, Miwa G, Gan LS. Xia CQ, et al. Among authors: miwa g. Drug Metab Dispos. 2005 May;33(5):637-43. doi: 10.1124/dmd.104.003442. Epub 2005 Feb 16. Drug Metab Dispos. 2005. PMID: 15716365

10

Elucidation of potential bortezomib response markers in mutliple myeloma patients.

Hsieh FY, Tengstrand E, Pekol TM, Guerciolini R, Miwa G. Hsieh FY, et al. Among authors: miwa g. J Pharm Biomed Anal. 2009 Jan 15;49(1):115-22. doi: 10.1016/j.jpba.2008.09.053. Epub 2008 Oct 17. J Pharm Biomed Anal. 2009. PMID: 19062221

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