Erlacher MD - Search Results

1

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.

Erlacher MD, Lang K, Shankaran N, Wotzel B, Hüttenhofer A, Micura R, Mankin AS, Polacek N. Erlacher MD, et al. Nucleic Acids Res. 2005 Mar 14;33(5):1618-27. doi: 10.1093/nar/gki308. Print 2005. Nucleic Acids Res. 2005. PMID: 15767286 Free PMC article.

2

Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2'-OH at A2451 of 23S rRNA.

Erlacher MD, Lang K, Wotzel B, Rieder R, Micura R, Polacek N. Erlacher MD, et al. J Am Chem Soc. 2006 Apr 5;128(13):4453-9. doi: 10.1021/ja0588454. J Am Chem Soc. 2006. PMID: 16569023

3

An intact ribose moiety at A2602 of 23S rRNA is key to trigger peptidyl-tRNA hydrolysis during translation termination.

Amort M, Wotzel B, Bakowska-Zywicka K, Erlacher MD, Micura R, Polacek N. Amort M, et al. Among authors: erlacher md. Nucleic Acids Res. 2007;35(15):5130-40. doi: 10.1093/nar/gkm539. Epub 2007 Jul 26. Nucleic Acids Res. 2007. PMID: 17660192 Free PMC article.

4

Ribosomal catalysis: the evolution of mechanistic concepts for peptide bond formation and peptidyl-tRNA hydrolysis.

Erlacher MD, Polacek N. Erlacher MD, et al. RNA Biol. 2008 Jan-Mar;5(1):5-12. doi: 10.4161/rna.5.1.5922. Epub 2008 Mar 18. RNA Biol. 2008. PMID: 18388484 Free article.

5

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis.

Lang K, Erlacher M, Wilson DN, Micura R, Polacek N. Lang K, et al. Chem Biol. 2008 May;15(5):485-92. doi: 10.1016/j.chembiol.2008.03.014. Epub 2008 Apr 24. Chem Biol. 2008. PMID: 18439847

6

The role of the universally conserved A2450-C2063 base pair in the ribosomal peptidyl transferase center.

Chirkova A, Erlacher MD, Clementi N, Zywicki M, Aigner M, Polacek N. Chirkova A, et al. Among authors: erlacher md. Nucleic Acids Res. 2010 Aug;38(14):4844-55. doi: 10.1093/nar/gkq213. Epub 2010 Apr 7. Nucleic Acids Res. 2010. PMID: 20375101 Free PMC article.

7

Generation of chemically engineered ribosomes for atomic mutagenesis studies on protein biosynthesis.

Erlacher MD, Chirkova A, Voegele P, Polacek N. Erlacher MD, et al. Nat Protoc. 2011 May;6(5):580-92. doi: 10.1038/nprot.2011.306. Epub 2011 Apr 7. Nat Protoc. 2011. PMID: 21527916

8

Probing functions of the ribosomal peptidyl transferase center by nucleotide analog interference.

Erlacher MD, Polacek N. Erlacher MD, et al. Methods Mol Biol. 2012;848:215-26. doi: 10.1007/978-1-61779-545-9_14. Methods Mol Biol. 2012. PMID: 22315072

9

The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis.

Koch M, Clementi N, Rusca N, Vögele P, Erlacher M, Polacek N. Koch M, et al. RNA Biol. 2015;12(1):70-81. doi: 10.1080/15476286.2015.1017218. RNA Biol. 2015. PMID: 25826414 Free PMC article.

10

Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code.

Hoernes TP, Clementi N, Faserl K, Glasner H, Breuker K, Lindner H, Hüttenhofer A, Erlacher MD. Hoernes TP, et al. Among authors: erlacher md. Nucleic Acids Res. 2016 Jan 29;44(2):852-62. doi: 10.1093/nar/gkv1182. Epub 2015 Nov 17. Nucleic Acids Res. 2016. PMID: 26578598 Free PMC article.

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