Zhang HC - Search Results

1

In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.

Costanzo MJ, Almond HR Jr, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE. Costanzo MJ, et al. Among authors: zhang hc. J Med Chem. 2005 Mar 24;48(6):1984-2008. doi: 10.1021/jm0303857. J Med Chem. 2005. PMID: 15771442

2

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

Zhang HC, White KB, McComsey DF, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE. Zhang HC, et al. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2199-203. doi: 10.1016/s0960-894x(03)00325-1. Bioorg Med Chem Lett. 2003. PMID: 12798334

3

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE. Zhang HC, et al. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53. doi: 10.1016/s0960-894x(03)00644-9. Bioorg Med Chem Lett. 2003. PMID: 12941331

4

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Ye H, Conway BR, Derian CK, Addo MF, Kuo GH, Hecker LR, Croll DR, Li J, Westover L, Xu JZ, Look R, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE. Zhang HC, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3245-50. doi: 10.1016/j.bmcl.2004.03.090. Bioorg Med Chem Lett. 2004. PMID: 15149684

5

Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1).

Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK. Maryanoff BE, et al. Among authors: zhang hc. Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar;1(1):13-36. doi: 10.2174/1568016033356724. Curr Med Chem Cardiovasc Hematol Agents. 2003. PMID: 15317288 Review.

6

Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

Zhang HC, Derian CK, McComsey DF, White KB, Ye H, Hecker LR, Li J, Addo MF, Croll D, Eckardt AJ, Smith CE, Li Q, Cheung WM, Conway BR, Emanuel S, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE. Zhang HC, et al. J Med Chem. 2005 Mar 24;48(6):1725-8. doi: 10.1021/jm049478u. J Med Chem. 2005. PMID: 15771419

7

Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Boñaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE. Zhang HC, et al. Bioorg Med Chem Lett. 2007 May 15;17(10):2863-8. doi: 10.1016/j.bmcl.2007.02.059. Epub 2007 Feb 25. Bioorg Med Chem Lett. 2007. PMID: 17350261

8

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.

Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE. Costanzo MJ, et al. Among authors: zhang hc. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2114-21. doi: 10.1016/j.bmcl.2008.01.093. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18272363

9

Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues.

Maryanoff BE, Zhang HC, Greco MN, Glover KA, Kauffman JA, Andrade-Gordon P. Maryanoff BE, et al. Among authors: zhang hc. Bioorg Med Chem. 1995 Aug;3(8):1025-38. doi: 10.1016/0968-0896(95)00098-2. Bioorg Med Chem. 1995. PMID: 7582977

10

Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.

Costanzo MJ, Maryanoff BE, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Kauffman JA, Lewis JM, Krishnan R, Tulinsky A. Costanzo MJ, et al. Among authors: zhang hc. J Med Chem. 1996 Aug 2;39(16):3039-43. doi: 10.1021/jm9603274. J Med Chem. 1996. PMID: 8759623 No abstract available.

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